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Literature summary for 2.3.1.184 extracted from
- LuxR-type quorum-sensing regulators that are detached from common scents (2010), Mol. Microbiol., 77, 1072-1082.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene expI, is transcribed convergently and overlapping at their 3' ends with gene expR | Dickeya chrysanthemi |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-oxo-octanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Agrobacterium tumefaciens | TraI synthesizes primarily 3-oxo-octanoyl homoserine lactone | [acyl-carrier protein] + S-methyl-5'-thioadenosine + 3-oxo-octanoyl-L-homoserine lactone | - |
? |  |
| 3-oxododecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Pseudomonas aeruginosa | LasI | [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxododecanoyl-L-homoserine lactone | - |
? | |
| 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Aliivibrio fischeri | - |
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone | - |
? | |
| 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Yersinia pseudotuberculosis | - |
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone | - |
? | |
| 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Dickeya chrysanthemi | - |
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone | - |
? | |
| 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Pectobacterium carotovorum | - |
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone | - |
? | |
| 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Yersinia pestis | - |
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone | - |
? | |
| 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Pseudomonas syringae | - |
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone | - |
? | |
| 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Yersinia enterocolitica | - |
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone | - |
? | |
| 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Pantoea stewartii | - |
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone | - |
? | |
| 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Serratia marcescens | SpnI (like EsaI) synthesizes primarily N-3-oxohexanoyl-L-homoserine lactone | [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone | - |
? | |
| 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Serratia marcescens SS-1 | SpnI (like EsaI) synthesizes primarily N-3-oxohexanoyl-L-homoserine lactone | [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone | - |
? | |
| an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Aliivibrio fischeri | - |
[acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
| an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Escherichia coli | - |
[acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
| an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Serratia marcescens | - |
[acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
| an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Dickeya chrysanthemi | - |
[acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
| an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Agrobacterium tumefaciens | - |
[acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
| an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Serratia sp. | - |
[acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
| an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Pantoea stewartii | - |
[acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
| an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Pseudomonas aeruginosa | - |
an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
| an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Yersinia pseudotuberculosis | - |
an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
| an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Pectobacterium carotovorum | - |
an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
| an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Yersinia pestis | - |
an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
| an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Pseudomonas syringae | - |
an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
| an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Yersinia enterocolitica | - |
an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
| an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Serratia sp. 39006 | - |
[acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
| an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Serratia marcescens SS-1 | - |
[acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
| butanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Pseudomonas aeruginosa | RhlI | [acyl-carrier protein] + S-methyl-5'-thioadenosine + butanoyl-L-homoserine lactone | - |
? | |
| additional information | Serratia sp. | SmaI synthesizes predominantly butanoyl-HSL and smaller amounts of hexanoyl-HSL | ? | - |
? | |
| additional information | Serratia sp. 39006 | SmaI synthesizes predominantly butanoyl-HSL and smaller amounts of hexanoyl-HSL | ? | - |
? | |
| N-butanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Serratia sp. | - |
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-butanoyl-L-homoserine lactone | - |
? | |
| N-butanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Serratia sp. 39006 | - |
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-butanoyl-L-homoserine lactone | - |
? | |
| N-hexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Serratia sp. | - |
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-hexanoyl-L-homoserine lactone | - |
? | |
| N-hexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Serratia sp. 39006 | - |
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-hexanoyl-L-homoserine lactone | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Agrobacterium tumefaciens | - |
- |
- |
| Aliivibrio fischeri | - |
- |
- |
| Dickeya chrysanthemi | - |
gene expI | - |
| Escherichia coli | - |
- |
- |
| Pantoea stewartii | - |
formerly Erwinia stewartii, gene esaI | - |
| Pectobacterium carotovorum | - |
formerly Erwinia carotovora, gene expI | - |
| Pseudomonas aeruginosa | - |
- |
- |
| Pseudomonas syringae | - |
gene psyI | - |
| Serratia marcescens | - |
- |
- |
| Serratia marcescens SS-1 | - |
- |
- |
| Serratia sp. | - |
gene smaI | - |
| Serratia sp. 39006 | - |
gene smaI | - |
| Yersinia enterocolitica | - |
gene yenI | - |
| Yersinia pestis | - |
gene ypeI | - |
| Yersinia pseudotuberculosis | - |
gene yspI | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-oxo-octanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Agrobacterium tumefaciens | [acyl-carrier protein] + S-methyl-5'-thioadenosine + 3-oxo-octanoyl-L-homoserine lactone | - |
? | |
| 3-oxo-octanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | TraI synthesizes primarily 3-oxo-octanoyl homoserine lactone | Agrobacterium tumefaciens | [acyl-carrier protein] + S-methyl-5'-thioadenosine + 3-oxo-octanoyl-L-homoserine lactone | - |
? | |
| 3-oxododecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | LasI | Pseudomonas aeruginosa | [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxododecanoyl-L-homoserine lactone | - |
? | |
| 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Aliivibrio fischeri | [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone | - |
? | |
| 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Serratia marcescens | [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone | - |
? | |
| 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Yersinia pseudotuberculosis | [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone | - |
? | |
| 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Dickeya chrysanthemi | [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone | - |
? | |
| 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Pectobacterium carotovorum | [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone | - |
? | |
| 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Yersinia pestis | [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone | - |
? | |
| 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Pseudomonas syringae | [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone | - |
? | |
| 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Yersinia enterocolitica | [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone | - |
? | |
| 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Pantoea stewartii | [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone | - |
? | |
| 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | SpnI (like EsaI) synthesizes primarily N-3-oxohexanoyl-L-homoserine lactone | Serratia marcescens | [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone | - |
? | |
| 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | PsyI synthesize predominantly N-3-oxohexanoyl-L-homoserine lactone | Pseudomonas syringae | [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone | - |
? | |
| 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Serratia marcescens SS-1 | [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone | - |
? | |
| 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | SpnI (like EsaI) synthesizes primarily N-3-oxohexanoyl-L-homoserine lactone | Serratia marcescens SS-1 | [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone | - |
? | |
| an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Aliivibrio fischeri | [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
| an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Escherichia coli | [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
| an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Serratia marcescens | [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
| an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Dickeya chrysanthemi | [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
| an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Agrobacterium tumefaciens | [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
| an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Serratia sp. | [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
| an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Pantoea stewartii | [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
| an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Serratia sp. 39006 | [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
| an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Serratia marcescens SS-1 | [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
| an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Pseudomonas aeruginosa | an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
| an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Yersinia pseudotuberculosis | an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
| an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Pectobacterium carotovorum | an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
| an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Yersinia pestis | an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
| an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Pseudomonas syringae | an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
| an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Yersinia enterocolitica | an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
| butanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | RhlI | Pseudomonas aeruginosa | [acyl-carrier protein] + S-methyl-5'-thioadenosine + butanoyl-L-homoserine lactone | - |
? | |
| additional information | SmaI synthesizes predominantly butanoyl-HSL and smaller amounts of hexanoyl-HSL | Serratia sp. | ? | - |
? | |
| additional information | SmaI synthesizes predominantly butanoyl-HSL and smaller amounts of hexanoyl-HSL | Serratia sp. 39006 | ? | - |
? | |
| N-butanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Serratia sp. | [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-butanoyl-L-homoserine lactone | - |
? | |
| N-butanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Serratia sp. 39006 | [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-butanoyl-L-homoserine lactone | - |
? | |
| N-hexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Serratia sp. | [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-hexanoyl-L-homoserine lactone | - |
? | |
| N-hexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Serratia sp. 39006 | [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-hexanoyl-L-homoserine lactone | - |
? | |
| octanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Escherichia coli | [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-octanoyl-L-homoserine lactone | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AHL synthase | - |
Aliivibrio fischeri |
| AHL synthase | - |
Escherichia coli |
| AHL synthase | - |
Pseudomonas aeruginosa |
| AHL synthase | - |
Serratia marcescens |
| AHL synthase | - |
Yersinia pseudotuberculosis |
| AHL synthase | - |
Dickeya chrysanthemi |
| AHL synthase | - |
Pectobacterium carotovorum |
| AHL synthase | - |
Yersinia pestis |
| AHL synthase | - |
Pseudomonas syringae |
| AHL synthase | - |
Agrobacterium tumefaciens |
| AHL synthase | - |
Serratia sp. |
| AHL synthase | - |
Yersinia enterocolitica |
| AHL synthase | - |
Pantoea stewartii |
| EsaI | - |
Pantoea stewartii |
| ExpI | - |
Dickeya chrysanthemi |
| ExpI | - |
Pectobacterium carotovorum |
| LasI | - |
Pseudomonas aeruginosa |
| LuxI | - |
Aliivibrio fischeri |
| PsyI | - |
Pseudomonas syringae |
| RhlI | - |
Pseudomonas aeruginosa |
| SmaI | - |
Serratia sp. |
| SpnI | - |
Serratia marcescens |
| TraI | - |
Agrobacterium tumefaciens |
| YenI | - |
Yersinia enterocolitica |
| YpeRI | - |
Yersinia pestis |
| YspRI | - |
Yersinia pseudotuberculosis |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Pectobacterium carotovorum | ExpR negatively regulates ExpI expression | down |
| Dickeya chrysanthemi | ExpR1 negatively regulates ExpI expression | down |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | ExpI is related to members of the LuxI family | Dickeya chrysanthemi |
| evolution | ExpI is related to members of the LuxI family | Pectobacterium carotovorum |
| malfunction | a smaI mutation abolishes the synthesis of the antibiotic carbapenem, the pigment prodigiosin, and several hydrolytic enzymes, while a smaR smaI double mutant restores their production | Serratia sp. |
| malfunction | an expR-virR-expI triple mutant is a phenocopy of the virR-expI double mutant, suggesting that ExpR does not play any role in regulating these genes. Exoenzyme production in a virR-expI mutant is still induced at high cell density, rather than constitutive | Pectobacterium carotovorum |
| malfunction | disruption of esaI caused a sharp decrease in exopolysaccharide accumulation, and production was restored by adding N-3-oxohexanoyl-L-homoserine lactone. EsaR mutants overproduce the same exopolysaccharide, indicating that null mutations in esaR and esaI have opposite phenotypes | Pantoea stewartii |
| malfunction | mutation of expI abolishes production of two N-acyl-L-homoserine lactones, but does not affect the production of a third one, suggesting the existence of at least one more AHL synthase gene. Mutations of expI and expR have little effect on pectate lyase synthesis, which remains quorum-regulated | Dickeya chrysanthemi |
| additional information | LuxR is an N-3-oxohexanoyl-L-homoserine lactone sensor and an N-3-oxohexanoyl-L-homoserine lactone-dependent transcriptional activator of the luciferase operon. As a population of Vibrio fischeri cells grows in density, the concentration of external N-3-oxohexanoyl-L-homoserine lactone increases. When the concentration of this signal reaches the nanomolar range, its passive efflux from the cells becomes balanced by an influx, so that it can interact with LuxR. LuxR-OHHL complexes bind the promoter of the luxICDABEG operon and activate its transcription. LuxR structure, overview. Three amino acids clustered in the C-terminal domain of LuxR are required for positive control of transcription. Molecular mechanism of action of LuxR as transcription factor, overview | Aliivibrio fischeri |
| additional information | molecular mechanism of action of EsaR as transcription factor, overview | Pantoea stewartii |
| additional information | molecular mechanism of action of EsaR-type protein PsyR as transcription factor, overview | Pseudomonas syringae |
| additional information | molecular mechanism of action of ExpR as transcription factor, overview | Dickeya chrysanthemi |
| additional information | molecular mechanism of action of ExpR as transcription factor, overview | Pectobacterium carotovorum |
| additional information | molecular mechanism of action of LuxR-like YpeR as transcription factor, the organism encodes two LuxR/LuxI, e.g. the YpeI/YpeR, systems, overview | Yersinia pestis |
| additional information | molecular mechanism of action of LuxR-like YspR as transcription factor, the organism encodes two LuxR/LuxI, e.g. the YspI/YspR, systems, overview | Yersinia pseudotuberculosis |
| additional information | molecular mechanism of action of SmaR as transcription factor, LuxR-type protein SmaR activity is blocked by the cognate N-acyl-L-homoserine lactone, overview | Serratia sp. |
| additional information | molecular mechanism of action of SpnR as transcription factor, overview. SpnR directly represses target promoters, while the N-acyl-L-homoserine lactone synthesized by SpnI antagonizes SpnR. The spnR/I genes are located on at mobile genetic element, and SpnR represses transcription of the Tn3-type transposase of this element | Serratia marcescens |
| additional information | molecular mechanism of action of YenR as transcription factor, overview | Yersinia enterocolitica |
| additional information | the LasR protein of Pseudomonas aeruginosa is a central component of a regulatory web that controls the expression of hundreds of genes, some of which play direct roles in disease, molecular mechanism of action of LasR as transcription factor, it detects 3-oxododecanoyl-L-homoserine lactone, overview. The so-called orphan receptor QscR, which also detects 3-oxododecanoyl-L-homoserine lactone. The second quorum sensing receptor, RhlR, detects butanoyl-L-homoserine lactone and interacts with its cognate AHL synthase, RhlI. Unlike LuxR, LasR does not detectably release its N-acyl-homoserine lactone. It binds to six LasR-dependent promoters | Pseudomonas aeruginosa |
| physiological function | chemical communication within populations of bacteria enable them to estimate their population density, a process sometimes referred to as quorum sensing. Signalling among Proteobacteria often involves N-acyl-homoserine lactones, which have identical polar head groups and a variety of hydrophobic acyl groups that differ in length, oxidation, and desaturation. AHL signal molecules are often referred to as autoinducers. They are synthesized by LuxI-type AHL synthases. Most LuxR-type receptors, i.e. LuxR, LasR, and TraR, and SpnR in Serratia marcescens require N-acyl-homoserine lactones for function and in at least some cases, N-acyl-homoserine lactones are required for protein folding and protease resistance. The SpnI/SpnR system controls production of prodigiosin, endonuclease, and a surfactant that affects motility | Serratia marcescens |
| physiological function | chemical communication within populations of bacteria enable them to estimate their population density, a process sometimes referred to as quorum sensing. Signalling among Proteobacteria often involves N-acyl-homoserine lactones, which have identical polar head groups and a variety of hydrophobic acyl groups that differ in length, oxidation, and desaturation. AHL signal molecules are often referred to as autoinducers. They are synthesized by LuxI-type AHL synthases. Most LuxR-type receptors, i.e. LuxR, LasR, and TraR, and YenR in Yersinia enterocolitica require N-acyl-homoserine lactones for function and in at least some cases, N-acyl-homoserine lactones are required for protein folding and protease resistance | Yersinia enterocolitica |
| physiological function | chemical communication within populations of bacteria enable them to estimate their population density, a process sometimes referred to as quorum sensing. Signalling among Proteobacteria often involves N-acyl-homoserine lactones, which have identical polar head groups and a variety of hydrophobic acyl groups that differ in length, oxidation, and desaturation. AHL signal molecules are often referred to as autoinducers. They are synthesized by LuxI-type AHL synthases. Most LuxR-type receptors, i.e. LuxR, LasR, and TraR, EsaR in Pantoea stewartii require N-acyl-homoserine lactones for function and in at least some cases, N-acyl-homoserine lactones are required for protein folding and protease resistance. EsaR represses transcription of its own gene, but does not affect expression of esaI. Nevertheless EsaR does regulate EPS and is antagonized by N-3-oxohexanoyl-L-homoserine lactone | Pantoea stewartii |
| physiological function | chemical communication within populations of bacteria enable them to estimate their population density, a process sometimes referred to as quorum sensing. Signalling among Proteobacteria often involves N-acyl-homoserine lactones, which have identical polar head groups and a variety of hydrophobic acyl groups that differ in length, oxidation, and desaturation. AHL signal molecules are often referred to as autoinducers. They are synthesized by LuxI-type AHL synthases. Most LuxR-type receptors, i.e. LuxR, LasR, and TraR, or SdiA in Escherichia coli require N-acyl-homoserine lactones for function and in at least some cases, N-acyl-homoserine lactones are required for protein folding and protease resistance, SdiA binds N-octanoyl-L-homoserine lactone enhancing its solubility during protein synthesis | Escherichia coli |
| physiological function | chemical communication within populations of bacteria enable them to estimate their population density, a process sometimes referred to as quorum sensing. Signalling among Proteobacteria often involves N-acyl-homoserine lactones, which have identical polar head groups and a variety of hydrophobic acyl groups that differ in length, oxidation, and desaturation. AHL signal molecules are often referred to as autoinducers. They are synthesized by LuxI-type AHL synthases. Most LuxR-type receptors, i.e. LuxR, LasR, and TraR, require N-acyl-homoserine lactones for function and in at least some cases, N-acyl-homoserine lactones are required for protein folding and protease resistance | Aliivibrio fischeri |
| physiological function | chemical communication within populations of bacteria enable them to estimate their population density, a process sometimes referred to as quorum sensing. Signalling among Proteobacteria often involves N-acyl-homoserine lactones, which have identical polar head groups and a variety of hydrophobic acyl groups that differ in length, oxidation, and desaturation. AHL signal molecules are often referred to as autoinducers. They are synthesized by LuxI-type AHL synthases. Most LuxR-type receptors, i.e. LuxR, LasR, and TraR, require N-acyl-homoserine lactones for function and in at least some cases, N-acyl-homoserine lactones are required for protein folding and protease resistance | Yersinia pseudotuberculosis |
| physiological function | chemical communication within populations of bacteria enable them to estimate their population density, a process sometimes referred to as quorum sensing. Signalling among Proteobacteria often involves N-acyl-homoserine lactones, which have identical polar head groups and a variety of hydrophobic acyl groups that differ in length, oxidation, and desaturation. AHL signal molecules are often referred to as autoinducers. They are synthesized by LuxI-type AHL synthases. Most LuxR-type receptors, i.e. LuxR, LasR, and TraR, require N-acyl-homoserine lactones for function and in at least some cases, N-acyl-homoserine lactones are required for protein folding and protease resistance | Yersinia pestis |
| physiological function | chemical communication within populations of bacteria enable them to estimate their population density, a process sometimes referred to as quorum sensing. Signalling among Proteobacteria often involves N-acyl-homoserine lactones, which have identical polar head groups and a variety of hydrophobic acyl groups that differ in length, oxidation, and desaturation. AHL signal molecules are often referred to as autoinducers. They are synthesized by LuxI-type AHL synthases. Most LuxR-type receptors, i.e. LuxR, LasR, and TraR, require N-acyl-homoserine lactones for function and in at least some cases, N-acyl-homoserine lactones are required for protein folding and protease resistance | Pseudomonas syringae |
| physiological function | chemical communication within populations of bacteria enable them to estimate their population density, a process sometimes referred to as quorum sensing. Signalling among Proteobacteria often involves N-acyl-homoserine lactones, which have identical polar head groups and a variety of hydrophobic acyl groups that differ in length, oxidation, and desaturation. AHL signal molecules are often referred to as autoinducers. They are synthesized by LuxI-type AHL synthases. Most LuxR-type receptors, i.e. LuxR, LasR, and TraR, require N-acyl-homoserine lactones for function and in at least some cases, N-acyl-homoserine lactones are required for protein folding and protease resistance. The LasR/LasI system stimulates production of the RhlI/RhlR system, causing the two Pseudomonas aeruginosa quorum-sensing circuits to initiate sequentially | Pseudomonas aeruginosa |
| physiological function | chemical communication within populations of bacteria enable them to estimate their population density, a process sometimes referred to as quorum sensing. Signalling among Proteobacteria often involves N-acyl-homoserine lactones, which have identical polar head groups and a variety of hydrophobic acyl groups that differ in length, oxidation, and desaturation. AHL signal molecules are often referred to as autoinducers. They are synthesized by LuxI-type AHL synthases. Most LuxR-type receptors, i.e. LuxR, LasR, and TraR, require N-acyl-homoserine lactones for function and in at least some cases, N-acyl-homoserine lactones are required for protein folding and protease resistance. TraR is an 3-oxo-octanoyl-L-homoserine lactone-dependent activator of genes required for vegetative replication and conjugative transfer of the Ti plasmid, TraR binds these sites as a dimer and without cooperativity, structure, overview | Agrobacterium tumefaciens |
| physiological function | chemical communication within populations of bacteria enable them to estimate their population density, a process sometimes referred to as quorum sensing. Signalling among Proteobacteria often involves N-acyl-homoserine lactones, which have identical polar head groups and a variety of hydrophobic acyl groups that differ in length, oxidation, and desaturation. AHL signal molecules are often referred to as autoinducers. They are synthesized by LuxI-type AHL synthases. Most LuxR-type receptors, i.e. LuxR, LasR, and TraR, require N-acyl-homoserine lactones for function and in at least some cases, N-acyl-homoserine lactones are required for protein folding and protease resistanceCarR is also a LuxR homolog and directly activates the car operon. CarR is rather closely related to members of the EsaR family, which might suggest that its activity can be blocked by cognate N-acyl-L-homoserine lactones. CarR is often referred to as N-acyl-L-homoserine lactone-independent, as it was able to activate the car operon of Pectobacterium carotovorum in a strain lacking N-acyl-L-homoserine lactones. CarR is essential for transcription of the Serratia car operon and functions perfectly well in an N-acyl-L-homoserine lactone-defective strain. It still seems possible that CarR could be antagonized by N-acyl-L-homoserine lactones, although it functions in strains that produce N-butanoyl-L-homoserine lactone | Serratia sp. |
| physiological function | ExpI controls the expression of the corresponding genes encoding enzymes capable of degrading pectate, cellulose, and protein involved in maceration of plant tissues of the pathogen's host plants. Chemical communication within populations of bacteria enable them to estimate their population density, a process sometimes referred to as quorum sensing. Signalling among Proteobacteria often involves N-acyl-homoserine lactones, which have identical polar head groups and a variety of hydrophobic acyl groups that differ in length, oxidation, and desaturation. AHL signal molecules are often referred to as autoinducers. They are synthesized by LuxI-type AHL synthases. Most LuxR-type receptors, i.e. LuxR, LasR, and TraR, and ExpR1 and ExpR2 (or VirR) in Pectobacterium carotovorum, require N-acyl-homoserine lactones for function and in at least some cases, N-acyl-homoserine lactones are required for protein folding and protease resistance. Receptor ExpR2 or VirR, detects a broader variety of N-acyl-homoserine lactones than ExpR1, and VirR is solely responsible for exoenzyme production. CarR is also a LuxR homolog and directly activates the car operon. CarR is rather closely related to members of the EsaR family, which might suggest that its activity can be blocked by cognate N-acyl-L-homoserine lactones. CarR is often referred to as N-acyl-L-homoserine lactone-independent, as it was able to activate the car operon of Pectobacterium carotovorum in a strain lacking N-acyl-L-homoserine lactones. The CarR protein of Pectobacterium carotovorum requires N-3-oxohexanoyl-L-homoserine lactone synthesized by ExpI to activate the organism's car operon | Pectobacterium carotovorum |
| physiological function | ExpI controls the expression of the corresponding genes encoding enzymes capable of degrading pectate, cellulose, and protein involved in maceration of plant tissues of the pathogen's host plants. Chemical communication within populations of bacteria enable them to estimate their population density, a process sometimes referred to as quorum sensing. Signalling among Proteobacteria often involves N-acyl-homoserine lactones, which have identical polar head groups and a variety of hydrophobic acyl groups that differ in length, oxidation, and desaturation. AHL signal molecules are often referred to as autoinducers. They are synthesized by LuxI-type AHL synthases. Most LuxR-type receptors, i.e. LuxR, LasR, and TraR, require N-acyl-homoserine lactones for function and in at least some cases, N-acyl-homoserine lactones are required for protein folding and protease resistance. Apo-ExpR autorepresses its synthesis, while N-3-oxohexanoyl-L-homoserine lactone almost fully blocked autorepression | Dickeya chrysanthemi |
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Release 2023.1 (January 2023)
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