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Literature summary for 2.3.1.184 extracted from

  • Berger, M.; Neumann, A.; Schulz, S.; Simon, M.; Brinkhoff, T.
    Tropodithietic acid production in Phaeobacter gallaeciensis is regulated by N-acyl homoserine lactone-mediated quorum sensing (2011), J. Bacteriol., 193, 6576-6585.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.184

Protein Variants

Protein Variants Comment Organism
additional information construction of the mutant strain WP38 lacking pgaI and showing no AHL activity and reduced cell growth compared to the wild-type Phaeobacter inhibens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-hydroxydecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine Phaeobacter inhibens
-
 [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-hydroxydecanoyl-L-homoserine lactone
-
 ?
3-hydroxydecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine Phaeobacter inhibens DSM 17395
-
 [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-hydroxydecanoyl-L-homoserine lactone
-
 ?

Organism

Organism UniProt Comment Textmining
Phaeobacter inhibens
-
-
-
Phaeobacter inhibens DSM 17395
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-hydroxydecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Phaeobacter inhibens [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-hydroxydecanoyl-L-homoserine lactone
-
 ?
3-hydroxydecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Phaeobacter inhibens DSM 17395 [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-hydroxydecanoyl-L-homoserine lactone
-
 ?

Synonyms

Synonyms Comment Organism
AHL synthase
-
 Phaeobacter inhibens
PgaI
-
 Phaeobacter inhibens

General Information

General Information Comment Organism
physiological function PgaI is responsible for the synthesis of R-N-3-hydroxy-decanoyl -L-homoserine lactone, and PgaI can still produce R-N-3-hydroxy-decanoyl -L-homoserine lactone in a pgaR-negative background, indicating that PgaR is not essential for the production of R-N-3-hydroxy-decanoyl -L-homoserine lactone. tropodithietic acid production in Phaeobacter gallaeciensis is regulated by N-acyl homoserine lactone-mediated quorum sensing, which involves the luxR-luxI-like quorum-sensing system with AHL synthase PgaI. The LuxR-type transcriptional regulator, PgaR, and 3OH-C10-HSL or, alternatively, antibiotic tropodithietic acid are required to induce the expression of tdaA and subsequently for the production of TDA, overview Phaeobacter inhibens