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Literature summary for 2.3.1.180 extracted from

  • Cheng, K.; Xue, J.Y.; Zhu, H.L.
    Design, synthesis and antibacterial activity studies of thiazole derivatives as potent ecKAS III inhibitors (2013), Bioorg. Med. Chem. Lett., 23, 4235-4238.
    View publication on PubMed
Search for more literature for 2.3.1.180

Inhibitors

Inhibitors Comment Organism Structure
2-(3,4-diethoxyphenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
-
 Escherichia coli
2-(3-bromophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
-
 Escherichia coli
2-(3-bromophenyl)-N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]acetamide
-
 Escherichia coli
2-(3-chlorophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
-
 Escherichia coli
2-(3-methoxyphenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
-
 Escherichia coli
2-(4-bromophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
-
 Escherichia coli
2-(4-bromophenyl)-N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]acetamide
-
 Escherichia coli
2-(4-chlorophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
-
 Escherichia coli
2-(4-fluorophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
-
 Escherichia coli
2-phenyl-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
-
 Escherichia coli
kanamycin B
-
 Escherichia coli
additional information design, synthesis and antibacterial activity studies of thiazole derivatives as potent ecKAS III inhibitors, inhibitor antibacterial activity against the respective Gram-negative and Gram-positive bacterial strains, overview Escherichia coli
N-(4-(4-bromophenyl)thiazol-2-yl)-2-(3-chlorophenyl)acetamid the malonyl carboxylate forms hydrogen bonds to the backbone nitrogen of Phe304, inhibitor binding mode, overview Escherichia coli
N-(4-phenyl-1,3-thiazol-2-yl)benzamide
-
 Escherichia coli
N-(4-phenyl-1,3-thiazol-2-yl)morpholine-4-carboxamide
-
 Escherichia coli
N-(4-phenyl-1,3-thiazol-2-yl)naphthalene-1-carboxamide
-
 Escherichia coli
N-(4-phenyl-1,3-thiazol-2-yl)naphthalene-2-carboxamide
-
 Escherichia coli
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-(3,4-diethoxyphenyl)acetamide
-
 Escherichia coli
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-(3-methoxyphenyl)acetamide
-
 Escherichia coli
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-(4-chlorophenyl)acetamide
-
 Escherichia coli
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-(4-fluorophenyl)acetamide
-
 Escherichia coli
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-phenylacetamide
-
 Escherichia coli
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]benzamide
-
 Escherichia coli
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]morpholine-4-carboxamide
-
 Escherichia coli
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]naphthalene-1-carboxamide
-
 Escherichia coli
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]naphthalene-2-carboxamide
-
 Escherichia coli
penicillin G
-
 Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli P0A6R0 gene fabH
-

Synonyms

Synonyms Comment Organism
beta-ketoacyl-(acyl-carrier-protein) synthase III
-
 Escherichia coli
ecKAS III
-
 Escherichia coli

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0053
-
 pH and temperature not specified in the publication Escherichia coli N-(4-(4-bromophenyl)thiazol-2-yl)-2-(3-chlorophenyl)acetamid
0.0098
-
 pH and temperature not specified in the publication Escherichia coli 2-(3-bromophenyl)-N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]acetamide
0.0123
-
 pH and temperature not specified in the publication Escherichia coli 2-(3-chlorophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
0.0269
-
 pH and temperature not specified in the publication Escherichia coli 2-(3-bromophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
0.0293
-
 pH and temperature not specified in the publication Escherichia coli N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-(4-fluorophenyl)acetamide
0.0347
-
 pH and temperature not specified in the publication Escherichia coli N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-(4-chlorophenyl)acetamide
0.0384
-
 pH and temperature not specified in the publication Escherichia coli 2-(4-fluorophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
0.0418
-
 pH and temperature not specified in the publication Escherichia coli 2-(4-chlorophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
0.0481
-
 pH and temperature not specified in the publication Escherichia coli 2-(4-bromophenyl)-N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]acetamide
0.0656
-
 pH and temperature not specified in the publication Escherichia coli N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-(3-methoxyphenyl)acetamide