Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.180 extracted from

  • Li, Z.L.; Li, Q.S.; Zhang, H.J.; Hu, Y.; Zhu, D.D.; Zhu, H.L.
    Design, synthesis and biological evaluation of urea derivatives from o-hydroxybenzylamines and phenylisocyanate as potential FabH inhibitors (2011), Bioorg. Med. Chem., 19, 4413-4420.
    View publication on PubMed
Search for more literature for 2.3.1.180

Cloned(Commentary)

Cloned (Comment) Organism
overexpressed in Escherichia coli DH10B cells using the pET30 vector, selenomethionine-substituted protein expressed in Escherichia coli BL21(DE3) Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
1-(2-chlorophenyl)-1-(3,5-dibromo-2-hydroxybenzyl)-3-phenylurea
-
 Escherichia coli
1-(3,5-dibromo-2-hydroxybenzyl)-1-(4-fluorophenyl)-3-phenylurea
-
 Escherichia coli
1-(4-chlorophenyl)-1-(3,5-dibromo-2-hydroxybenzyl)-3-phenylurea
-
 Escherichia coli
1-(5-bromo-2-hydroxybenzyl)-1-(2-bromophenyl)-3-phenylurea
-
 Escherichia coli
1-(5-bromo-2-hydroxybenzyl)-1-(2-chlorophenyl)-3-phenylurea
-
 Escherichia coli
1-(5-bromo-2-hydroxybenzyl)-1-(2-fluorophenyl)-3-phenylurea
-
 Escherichia coli
1-(5-bromo-2-hydroxybenzyl)-1-(4-bromophenyl)-3-phenylurea
-
 Escherichia coli
1-(5-bromo-2-hydroxybenzyl)-1-(4-chlorophenyl)-3-phenylurea
-
 Escherichia coli
1-(5-bromo-2-hydroxybenzyl)-1-(4-fluorophenyl)-3-phenylurea
-
 Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
to homogeneity in three chromatographic steps (Q-Sepharose, MonoQ, and hydroxyapatite) Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
malonyl-ACP + acetyl-CoA
-
 Escherichia coli CO2 + CoA + acetoacetyl-ACP
-
 ?

Synonyms

Synonyms Comment Organism
beta-ketoacyl-acyl carrier protein synthase III
-
 Escherichia coli
FabH
-
 Escherichia coli

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0047
-
 pH 7.0, temperature not specified in the publication Escherichia coli 1-(5-bromo-2-hydroxybenzyl)-1-(4-chlorophenyl)-3-phenylurea
0.0066
-
 pH 7.0, temperature not specified in the publication Escherichia coli 1-(5-bromo-2-hydroxybenzyl)-1-(4-fluorophenyl)-3-phenylurea
0.0101
-
 pH 7.0, temperature not specified in the publication Escherichia coli 1-(4-chlorophenyl)-1-(3,5-dibromo-2-hydroxybenzyl)-3-phenylurea
0.0218
-
 pH 7.0, temperature not specified in the publication Escherichia coli 1-(5-bromo-2-hydroxybenzyl)-1-(2-chlorophenyl)-3-phenylurea
0.0374
-
 pH 7.0, temperature not specified in the publication Escherichia coli 1-(5-bromo-2-hydroxybenzyl)-1-(2-fluorophenyl)-3-phenylurea
0.041
-
 pH 7.0, temperature not specified in the publication Escherichia coli 1-(5-bromo-2-hydroxybenzyl)-1-(4-bromophenyl)-3-phenylurea
0.0515
-
 pH 7.0, temperature not specified in the publication Escherichia coli 1-(2-chlorophenyl)-1-(3,5-dibromo-2-hydroxybenzyl)-3-phenylurea
0.0564
-
 pH 7.0, temperature not specified in the publication Escherichia coli 1-(5-bromo-2-hydroxybenzyl)-1-(2-bromophenyl)-3-phenylurea
0.0717
-
 pH 7.0, temperature not specified in the publication Escherichia coli 1-(3,5-dibromo-2-hydroxybenzyl)-1-(4-fluorophenyl)-3-phenylurea