Application | Comment | Organism |
---|---|---|
drug development | FabH is an attractive target for the development of antibacterial agents | Escherichia coli |
Cloned (Comment) | Organism |
---|---|
expression of the native and the selenomethionine-labeled enzyme in Escherichia coli strain DH10B | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-hydroxy-2-phenyl-7-(2-(piperazin-1-yl)ethoxy)-4H-chromen-4-one | a chrysine derivative, strong inhibition with MIC of 0.001560.00625 mg/ml, molecular docking simulation and determination of inhibitor binding structure at the active site, overview | Escherichia coli | |
5-hydroxy-2-phenyl-7-(2-(piperidin-1-yl)ethoxy)-4H-chromen-4-one | - |
Escherichia coli | |
5-hydroxy-2-phenyl-7-(2-(pyrrolidin-1-yl)ethoxy)-4H-chromen-4-one | - |
Escherichia coli | |
5-hydroxy-2-phenyl-7-(3-(2-hydroxyethylamino)propoxy)-4H-chromen-4-one | - |
Escherichia coli | |
5-hydroxy-2-phenyl-7-(3-(piperazin-1-yl)propoxy)-4H-chromen-4-one | - |
Escherichia coli | |
5-hydroxy-2-phenyl-7-(3-(propylamino)propoxy)-4H-chromen-4-one | - |
Escherichia coli | |
5-hydroxy-7-(2-(4-methylpiperazin-1-yl)ethoxy)-2-phenyl-4H-chromen-4-one | - |
Escherichia coli | |
5-hydroxy-7-(3-(4-methylpiperazin-1-yl)propoxy)-2-phenyl-4H-chromen-4-one | - |
Escherichia coli | |
7-(2-(dibutylamino)ethoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one | - |
Escherichia coli | |
7-(2-(diethylamino)ethoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one | - |
Escherichia coli | |
7-(2-(dipropylamino)ethoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one | - |
Escherichia coli | |
7-(2-(propylamino)ethoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one | - |
Escherichia coli | |
7-(3-(dibutylamino)propoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one | - |
Escherichia coli | |
7-(3-(diethylamino)propoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one | - |
Escherichia coli | |
7-(3-(dipropylamino)propoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one | - |
Escherichia coli | |
chrysine | i.e 1,5,7-dihydroxyflavone | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + malonyl-[acyl-carrier protein] | Escherichia coli | - |
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
additional information | Escherichia coli | FabH catalyzes the initial step of fatty acid biosynthesis via a type II fatty acid synthase, FabH has an important role as essential enzyme combined with unique structural features and ubiquitous occurrence | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P0A6R0 | gene fabH | - |
Purification (Comment) | Organism |
---|---|
recombinant native and selenomethionine-labeled enzyme from Escherichia coli strain DH10B to homogeneity by two different steps of anion exchange and a step of hydroxyapatite chromatography | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + malonyl-[acyl-carrier protein] | - |
Escherichia coli | 3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
additional information | FabH catalyzes the initial step of fatty acid biosynthesis via a type II fatty acid synthase, FabH has an important role as essential enzyme combined with unique structural features and ubiquitous occurrence | Escherichia coli | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
beta-ketoacyl-acyl carrier protein synthase III | - |
Escherichia coli |
FabH | - |
Escherichia coli |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Escherichia coli |