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Literature summary for 2.3.1.180 extracted from

  • Li, H.Q.; Shi, L.; Li, Q.S.; Liu, P.G.; Luo, Y.; Zhao, J.; Zhu, H.L.
    Synthesis of C(7) modified chrysin derivatives designing to inhibit beta-ketoacyl-acyl carrier protein synthase III (FabH) as antibiotics (2009), Bioorg. Med. Chem., 17, 6264-6269.
    View publication on PubMed

Application

Application Comment Organism
drug development FabH is an attractive target for the development of antibacterial agents Escherichia coli

Cloned(Commentary)

Cloned (Comment) Organism
expression of the native and the selenomethionine-labeled enzyme in Escherichia coli strain DH10B Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
5-hydroxy-2-phenyl-7-(2-(piperazin-1-yl)ethoxy)-4H-chromen-4-one a chrysine derivative, strong inhibition with MIC of 0.00156–0.00625 mg/ml, molecular docking simulation and determination of inhibitor binding structure at the active site, overview Escherichia coli
5-hydroxy-2-phenyl-7-(2-(piperidin-1-yl)ethoxy)-4H-chromen-4-one
-
Escherichia coli
5-hydroxy-2-phenyl-7-(2-(pyrrolidin-1-yl)ethoxy)-4H-chromen-4-one
-
Escherichia coli
5-hydroxy-2-phenyl-7-(3-(2-hydroxyethylamino)propoxy)-4H-chromen-4-one
-
Escherichia coli
5-hydroxy-2-phenyl-7-(3-(piperazin-1-yl)propoxy)-4H-chromen-4-one
-
Escherichia coli
5-hydroxy-2-phenyl-7-(3-(propylamino)propoxy)-4H-chromen-4-one
-
Escherichia coli
5-hydroxy-7-(2-(4-methylpiperazin-1-yl)ethoxy)-2-phenyl-4H-chromen-4-one
-
Escherichia coli
5-hydroxy-7-(3-(4-methylpiperazin-1-yl)propoxy)-2-phenyl-4H-chromen-4-one
-
Escherichia coli
7-(2-(dibutylamino)ethoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one
-
Escherichia coli
7-(2-(diethylamino)ethoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one
-
Escherichia coli
7-(2-(dipropylamino)ethoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one
-
Escherichia coli
7-(2-(propylamino)ethoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one
-
Escherichia coli
7-(3-(dibutylamino)propoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one
-
Escherichia coli
7-(3-(diethylamino)propoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one
-
Escherichia coli
7-(3-(dipropylamino)propoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one
-
Escherichia coli
chrysine i.e 1,5,7-dihydroxyflavone Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + malonyl-[acyl-carrier protein] Escherichia coli
-
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
?
additional information Escherichia coli FabH catalyzes the initial step of fatty acid biosynthesis via a type II fatty acid synthase, FabH has an important role as essential enzyme combined with unique structural features and ubiquitous occurrence ?
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli P0A6R0 gene fabH
-

Purification (Commentary)

Purification (Comment) Organism
recombinant native and selenomethionine-labeled enzyme from Escherichia coli strain DH10B to homogeneity by two different steps of anion exchange and a step of hydroxyapatite chromatography Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + malonyl-[acyl-carrier protein]
-
Escherichia coli 3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
?
additional information FabH catalyzes the initial step of fatty acid biosynthesis via a type II fatty acid synthase, FabH has an important role as essential enzyme combined with unique structural features and ubiquitous occurrence Escherichia coli ?
-
?

Synonyms

Synonyms Comment Organism
beta-ketoacyl-acyl carrier protein synthase III
-
Escherichia coli
FabH
-
Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Escherichia coli