Literature summary for 2.3.1.179 extracted from

Lewis, R.A.; Nunns, L.; Thirlway, J.; Carroll, K.; Smith, C.P.; Micklefield, J.
Active site modification of the beta-ketoacyl-ACP synthase FabF3 of Streptomyces coelicolor affects the fatty acid chain length of the CDA lipopeptides (2011), Chem. Commun. (Camb. ), 47, 1860-1862.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21(DE3)	Streptomyces coelicolor

Protein Variants

Protein Variants	Comment	Organism
F107I	less efficient than wild type protein	Streptomyces coelicolor
F107L	less efficient than wild type protein	Streptomyces coelicolor
F107S	suggested that the Ser residue has less significant effects than the Ile and Leu mutations	Streptomyces coelicolor

Organism

Organism	UniProt	Comment	Textmining
Streptomyces coelicolor	-	-	-

Synonyms

Synonyms	Comment	Organism
beta-ketoacyl-ACP synthase FabF3	KAS-II homologue	Streptomyces coelicolor

General Information

General Information	Comment	Organism
physiological function	encoded in the gene cluster required for biosynthesis of the calcium dependent antibiotics	Streptomyces coelicolor

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Release 2023.1 (January 2023)