Literature summary for 2.3.1.179 extracted from

Sharma, S.; Sharma, S.K.; Surolia, N.; Surolia, A.
beta-Ketoacyl-ACP synthase I/II from Plasmodium falciparum (PfFabB/F) - is it B or F? (2009), IUBMB Life, 61, 658-662.

Search for more literature for 2.3.1.179

Cloned(Commentary)

Cloned (Comment)	Organism
gene PffabB/Fm, FabB/F is encoded at locus MAL6P1.165, cloning and expression, expression in and complementation of Escherichia coli strain CY244, which is deficient in FabB and FabF, the latter by mutations S220N and G262M	Plasmodium falciparum

Protein Variants

Protein Variants	Comment	Organism
additional information	in vitro complementation of the enzyme-deficient Escherichia coli CY244 strain, shows that Plasmodium falciparum FabB/F functions like Escherichia coli FabF as the growth of the mutant cells can be rescued only in the presence of oleic acid	Plasmodium falciparum

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	-	gene PffabB/F	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(Z)-hexadec-9-enoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]	-	Plasmodium falciparum	(Z)-3-oxooctadeca-11-enoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]	-	?
additional information	PfFabB/F does not elongate C16DELTA9-[acyl-carrier-protein], substrate specificity, overview	Plasmodium falciparum	?	-	?

Synonyms

Synonyms	Comment	Organism
beta-ketoacyl-acyl carrier protein synthase I/II	-	Plasmodium falciparum
FabB/F	-	Plasmodium falciparum

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	assay at	Plasmodium falciparum

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Release 2023.1 (January 2023)