Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a target for antibacterial drugs | Staphylococcus aureus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | in vivo inhibition assays | Staphylococcus aureus | |
platencin | exhibits a broad-spectrum Gram-positive antibacterial activity through inhibition of fatty acid biosynthesis, targets the two essential proteins, beta-ketoacyl-[acyl carrier protein] synthase II and III, i.e. FabF and FabH, FabF IC50: 113 nM, overview | Staphylococcus aureus | |
platensimycin | from a strain of Streptomyces platensis MA7339, specifically targets FabF, IC50: 290 nM, exhibits Gram-positive antibacterial activity | Staphylococcus aureus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Staphylococcus aureus | - |
- |
- |
Staphylococcus aureus | - |
methicillin-resistant and vancomycin-resistant strains | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
development of an elongation assay with FabF and FabH, EC 2.3.1.41 | Staphylococcus aureus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | FabF produces C14 long-chain beta-ketoacyl-ACP | Staphylococcus aureus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
beta-ketoacyl-[acyl carrier protein (ACP)] synthase II | - |
Staphylococcus aureus |
beta-ketoacyl-[acyl-carrier protein (ACP)] synthase II | - |
Staphylococcus aureus |
FabF | - |
Staphylococcus aureus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Staphylococcus aureus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Staphylococcus aureus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
IC50 for platencin is 0.00195 ng/ml, IC50 for platensimycin is 0.00013 ng/ml | Staphylococcus aureus | additional information | |
0.000113 | - |
exhibits a broad-spectrum Gram-positive antibacterial activity through inhibition of fatty acid biosynthesis, targets the two essential proteins, beta-ketoacyl-[acyl carrier protein] synthase II and III, i.e. FabF and FabH, FabF IC50: 113 nM, overview | Staphylococcus aureus | platencin | |
0.00029 | - |
from a strain of Streptomyces platensis MA7339, specifically targets FabF, IC50: 290 nM, exhibits Gram-positive antibacterial activity | Staphylococcus aureus | platensimycin |