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Literature summary for 2.3.1.177 extracted from

  • Liu, B.; Raeth, T.; Beuerle, T.; Beerhues, L.
    Biphenyl synthase, a novel type III polyketide synthase (2007), Planta, 225, 1495-1503.
    View publication on PubMed
Search for more literature for 2.3.1.177

Cloned(Commentary)

Cloned (Comment) Organism
-
 Sorbus aucuparia

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.7
-
 benzoyl-CoA pH 7.0, 35°C Sorbus aucuparia
6.2
-
 malonyl-CoA pH 7.0, 35°C Sorbus aucuparia

Organism

Organism UniProt Comment Textmining
Sorbus aucuparia Q27Z07 enzyme expression is rapidly, strongly and transiently induced by yeast extract treatment
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
malonyl-CoA + 2-hydroxybenzoyl-CoA 52% of the activity with benzoyl-CoA Sorbus aucuparia CoA + 2-hydroxybenzoyltriacetic acid lactone + CO2
-
 ?
malonyl-CoA + 3-hydroxybenzoyl-CoA 68% of the activity with benzoyl-CoA Sorbus aucuparia CoA + ? + CO2
-
 ?
malonyl-CoA + benzoyl-CoA
-
 Sorbus aucuparia CoA + 3,5-dihydroxybiphenyl + CO2 low amounts of benzoyldiacetic acid lactone are synthesized as derailment product ?
additional information benzoyl-CoA is the preferred starter substrate. Enzyme does not accept 4-hydroxybenzoyl-CoA or CoA-linked cinnamic acids such as 4-coumaroyl-CoA Sorbus aucuparia ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
35
-
-
 Sorbus aucuparia

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0072
-
 benzoyl-CoA pH 7.0, 35°C Sorbus aucuparia

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5 7
-
 Sorbus aucuparia