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Literature summary for 2.3.1.176 extracted from

  • Cerqueira, D.; Tran, U.; Romaker, D.; Abreu, J.; Wessely, O.
    Sterol carrier protein 2 regulates proximal tubule size in the Xenopus pronephric kidney by modulating lipid rafts (2014), Dev. Biol., 394, 54-64.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Xenopus laevis
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Source Tissue

Source Tissue Comment Organism Textmining
kidney mRNA is strongly expressed in differentiated epithelial structures of the pronephric kidney Xenopus laevis
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General Information

General Information Comment Organism
physiological function knockdown of scp2 does not interfere with the patterning of the kidney along its proximo-distal axis, but dramatically decreases the size of the kidney, in particular the proximal tubules. This phenotype is accompanied by a reduction of lipid rafts, but is independent of the peroxisomal or transcriptional activities of scp2. Disrupting lipid microdomains by inhibiting cholesterol synthesis phenocopies the defects seen in scp2 morphants Xenopus laevis