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Literature summary for 2.3.1.169 extracted from

  • Tan, X.; Surovtsev, I.V.; Lindahl, P.A.
    Kinetics of CO insertion and acetyl group transfer steps, and a model of the acetyl-CoA synthase catalytic mechanism (2006), J. Am. Chem. Soc., 128, 12331-12338.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Moorella thermoacetica
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Reaction

Reaction Comment Organism Reaction ID
acetyl-CoA + a [Co(I) corrinoid Fe-S protein] = CO + CoA + a [methyl-Co(III) corrinoid Fe-S protein] stopped-flow analysis of two steps within the catalytic cycle. Vast majority of enzymes within a population should be in the methylated form suggesting that the following CO insertion step is rate limiting. Reaction rate is most sensitively affected by a change in the rate coefficient associated with the CO insertion step Moorella thermoacetica

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
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additional information stopped-flow analysis of two steps within the catalytic cycle Moorella thermoacetica