Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe | the Ni-Fe4S4-5C cluster of enzyme catalyses the reversible reduction of CO2 to CO and is located in the beta-subunit. | Moorella thermoacetica | |
Fe | corrinoid/iron-sulfur protein required | Moorella thermoacetica | |
Ni | the Ni-Fe4S4-5C cluster of enzyme catalyses the reversible reduction of CO2 to CO and is located in the beta-subunit. | Moorella thermoacetica | |
Ni | enzyme contains nickel in the A-cluster of the enzyme | Moorella thermoacetica |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Moorella thermoacetica | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
acetyl-CoA + a [Co(I) corrinoid Fe-S protein] = CO + CoA + a [methyl-Co(III) corrinoid Fe-S protein] | pathway | Moorella thermoacetica | |
acetyl-CoA + a [Co(I) corrinoid Fe-S protein] = CO + CoA + a [methyl-Co(III) corrinoid Fe-S protein] | the Ni-Fe4S4-5C cluster of enzyme catalyses the reversible reduction of CO2 to CO and is located in the beta-subunit. CO generated at this site migrates through the tunnel to the A-cluster, located in the alpha-subunit, where it reacts with CoA and a methyl group to generate acetyl-CoA. During catalysis, the two sites are mechanistically coupled. | Moorella thermoacetica |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CO + H2O | the NiFe4S4-5C cluster catalyses the reversible oxidation of CO to CO2 | Moorella thermoacetica | CO2 + H+ + electron | - |
r |
Subunits | Comment | Organism |
---|---|---|
tetramer | alpha,beta, containing two unique Ni-Fe-S active sites connected by a molecular tunnel | Moorella thermoacetica |