Literature summary for 2.3.1.165 extracted from

Wattanachaisaereekul, S.; Lantz, A.E.; Nielsen, M.L.; Nielsen, J.
Production of the polyketide 6-MSA in yeast engineered for increased malonyl-CoA supply (2008), Metab. Eng., 10, 246-254.

Search for more literature for 2.3.1.165

Application

Application	Comment	Organism
biotechnology	production of 6-methylsalicylic acid which is used as human pharmaceutical	Penicillium griseofulvum
medicine	production of 6-methylsalicylic acid which is used as human pharmaceutical	Penicillium griseofulvum

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Saccharomyces cerevisiae	Penicillium griseofulvum

Protein Variants

Protein Variants	Comment	Organism
additional information	Saccharomyces cerevisiae strain IBT100083 with a ACC1-TEF1 promoter produces high levels of acetyl-CoA carboxylase (ACC1) which catalyzes the conversion of acetyl-CoA to malonyl-CoA. Hence, more substrate for 6-methylsalicylic acid synthase is available resulting in a higher 6-MSA production.	Penicillium griseofulvum

Organism

Organism	UniProt	Comment	Textmining
Penicillium griseofulvum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + malonyl-CoA + NADPH	-	Penicillium griseofulvum	6-methylsalicylate + CoA + CO2 + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
6-methylsalicylic acid synthase	-	Penicillium griseofulvum
6-MSAS	-	Penicillium griseofulvum

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Release 2023.1 (January 2023)