Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | in order to activate 6-MSAS a 4'-phosphopantetheinyl transferase, PPTase, is required, therefor a Bacillus subtilis or a Aspergillus nidulans PPTase is coexpressed in yeast | Penicillium griseofulvum |
Application | Comment | Organism |
---|---|---|
biotechnology | functional heterologous expression of enzyme requires the presence of a 4-phosphoantetheinyl transferase for activation. Coexpression of both enzymes results in production of 6-methylsalicylic acid in good yields | Penicillium griseofulvum |
biotechnology | polyketides are a group of natural products that have gained much interest due to their use as antibiotics, cholesterol lowering agents, immunosuppressors and other drugs, it is therefor of general interest to transfer polyketide synthase genes into heterologous hosts that can overproduce the corresponding polyketides | Penicillium griseofulvum |
Cloned (Comment) | Organism |
---|---|
for expression in Saccharomyces cerevisiae | Penicillium griseofulvum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + malonyl-CoA + NADPH + H+ | Penicillium griseofulvum | - |
6-methylsalicylate + CoA + CO2 + NADP+ + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Penicillium griseofulvum | - |
expression in Saccharomyces cerevisiae | - |
Penicillium griseofulvum | P22367 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + malonyl-CoA + NADPH + H+ | - |
Penicillium griseofulvum | 6-methylsalicylate + CoA + CO2 + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
6-methylsalicylic-acid synthase | - |
Penicillium griseofulvum |
6-MSAS | - |
Penicillium griseofulvum |