Literature summary for 2.3.1.157 extracted from

Green, O.M.; McKenzie, A.R.; Shapiro, A.B.; Otterbein, L.; Ni, H.; Patten, A.; Stokes, S.; Albert, R.; Kawatkar, S.; Breed, J.
Inhibitors of acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 1: Hit to lead evaluation of a novel arylsulfonamide series (2012), Bioorg. Med. Chem. Lett., 22, 1510-1519.

Search for more literature for 2.3.1.157

Crystallization (Commentary)

Crystallization (Comment)	Organism
purified GlmU, hanging drop vapour diffusion method, 20 mg/ml protein in 25 mM TrisHCl, pH 7.5, 50 mM NaCl, 2 mM TCEP, is mixed with 2 mM inhibitor ligand, and incubated on ice for 30 min and centrifuged, then mixed with reservoir solution containing of 18-23% w/v PEG 3350, 200 mM ammonium sulfate and 100 mM PCTP, pH 7.0-8.0, 2-5 days, 20°C, X-ray diffraction structure determination and analysis	Streptococcus pneumoniae
purified GlmU, hanging drop vapour diffusion method, mixing of 8 mg/ml enzyme in 50 mM Tris/HCl, pH 8.0, 150 mM NaCl, 2 mM EDTA, 2 mM TCEP, with 2 mM inhibitor ligand, and with reservoir solution containing 1922% w/v PEG 3350 and either 100 mM PCTP, pH 5.0, 100-200 mM ammonium sulfate or 100 mM MMT, pH 6.0-7.0, and 400 mM ammonium sulfate, 20°C, 2-7 days, X-ray diffraction structure determination and analysis	Escherichia coli

Crystallization (Comment)

Organism

purified GlmU, hanging drop vapour diffusion method, 20 mg/ml protein in 25 mM TrisHCl, pH 7.5, 50 mM NaCl, 2 mM TCEP, is mixed with 2 mM inhibitor ligand, and incubated on ice for 30 min and centrifuged, then mixed with reservoir solution containing of 18-23% w/v PEG 3350, 200 mM ammonium sulfate and 100 mM PCTP, pH 7.0-8.0, 2-5 days, 20°C, X-ray diffraction structure determination and analysis

Streptococcus pneumoniae

purified GlmU, hanging drop vapour diffusion method, mixing of 8 mg/ml enzyme in 50 mM Tris/HCl, pH 8.0, 150 mM NaCl, 2 mM EDTA, 2 mM TCEP, with 2 mM inhibitor ligand, and with reservoir solution containing 1922% w/v PEG 3350 and either 100 mM PCTP, pH 5.0, 100-200 mM ammonium sulfate or 100 mM MMT, pH 6.0-7.0, and 400 mM ammonium sulfate, 20°C, 2-7 days, X-ray diffraction structure determination and analysis

Escherichia coli

Inhibitors

Inhibitors	Comment	Organism
(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid	-	Escherichia coli
(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid	-	Haemophilus influenzae
(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid	-	Staphylococcus aureus
(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid	-	Streptococcus pneumoniae
1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid	-	Escherichia coli
1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid	-	Haemophilus influenzae
1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid	-	Staphylococcus aureus
1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid	-	Streptococcus pneumoniae
2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid	-	Escherichia coli
2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid	-	Haemophilus influenzae
2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid	-	Staphylococcus aureus
2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid	-	Streptococcus pneumoniae
2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate	-	Escherichia coli
2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate	-	Haemophilus influenzae
2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate	-	Staphylococcus aureus
2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate	-	Streptococcus pneumoniae
4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid	-	Escherichia coli
4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid	-	Haemophilus influenzae
4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid	-	Staphylococcus aureus
4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid	-	Streptococcus pneumoniae
4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid	-	Escherichia coli
4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid	-	Haemophilus influenzae
4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid	-	Staphylococcus aureus
4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid	-	Streptococcus pneumoniae
4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid	-	Escherichia coli
4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid	-	Haemophilus influenzae
4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid	-	Staphylococcus aureus
4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid	-	Streptococcus pneumoniae
4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid	-	Escherichia coli
4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid	-	Haemophilus influenzae
4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid	-	Staphylococcus aureus
4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid	-	Streptococcus pneumoniae
4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid	-	Escherichia coli
4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid	-	Haemophilus influenzae
4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid	-	Staphylococcus aureus
4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid	-	Streptococcus pneumoniae
4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid	-	Escherichia coli
4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid	-	Haemophilus influenzae
4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid	-	Staphylococcus aureus
4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid	-	Streptococcus pneumoniae
methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate	-	Escherichia coli
methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate	-	Haemophilus influenzae
methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate	-	Staphylococcus aureus
methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate	-	Streptococcus pneumoniae
additional information	high throughput inhibitor screening for inhibition of the acetyltransferase domain of GlmU by a arylsulfonamide series	Escherichia coli
additional information	high throughput inhibitor screening for inhibition of the acetyltransferase domain of GlmU by a arylsulfonamide series	Haemophilus influenzae
additional information	high throughput inhibitor screening for inhibition of the acetyltransferase domain of GlmU by a arylsulfonamide series	Staphylococcus aureus
additional information	high throughput inhibitor screening for inhibition of the acetyltransferase domain of GlmU by a arylsulfonamide series	Streptococcus pneumoniae
N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide	-	Escherichia coli
N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide	-	Haemophilus influenzae
N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide	-	Staphylococcus aureus
N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide	-	Streptococcus pneumoniae
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine	-	Escherichia coli
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine	-	Haemophilus influenzae
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine	-	Staphylococcus aureus
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine	-	Streptococcus pneumoniae
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine	-	Escherichia coli
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine	-	Haemophilus influenzae
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine	-	Staphylococcus aureus
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine	-	Streptococcus pneumoniae
N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide	-	Escherichia coli
N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide	-	Haemophilus influenzae
N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide	-	Staphylococcus aureus
N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide	-	Streptococcus pneumoniae
N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide	-	Escherichia coli
N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide	-	Haemophilus influenzae
N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide	-	Staphylococcus aureus
N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide	-	Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide	-	Escherichia coli
N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide	-	Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide	-	Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide	-	Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide	the inhibitor binds at the C-terminal domain of GlmU engaging the A, B and C subunits of the trimer	Escherichia coli
N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide	the inhibitor binds at the C-terminal domain of GlmU engaging the A, B and C subunits of the trimer	Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide	the inhibitor binds at the C-terminal domain of GlmU engaging the A, B and C subunits of the trimer	Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide	the inhibitor binds at the C-terminal domain of GlmU engaging the A, B and C subunits of the trimer	Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide	-	Escherichia coli
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide	-	Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide	-	Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide	-	Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide	-	Escherichia coli
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide	-	Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide	-	Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide	-	Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide	-	Escherichia coli
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide	-	Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide	-	Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide	-	Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide	-	Escherichia coli
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide	-	Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide	-	Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide	-	Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide	-	Escherichia coli
N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide	-	Haemophilus influenzae
N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide	-	Staphylococcus aureus
N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide	-	Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide	-	Escherichia coli
N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide	-	Haemophilus influenzae
N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide	-	Staphylococcus aureus
N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide	-	Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide	-	Escherichia coli
N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide	-	Haemophilus influenzae
N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide	-	Staphylococcus aureus
N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide	-	Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide	-	Escherichia coli
N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide	-	Haemophilus influenzae
N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide	-	Staphylococcus aureus
N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide	-	Streptococcus pneumoniae
N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide	-	Escherichia coli
N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide	-	Haemophilus influenzae
N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide	-	Staphylococcus aureus
N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide	-	Streptococcus pneumoniae
N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide	-	Escherichia coli
N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide	-	Haemophilus influenzae
N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide	-	Staphylococcus aureus
N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide	-	Streptococcus pneumoniae
N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide	-	Escherichia coli
N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide	-	Haemophilus influenzae
N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide	-	Staphylococcus aureus
N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide	-	Streptococcus pneumoniae
N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide	-	Escherichia coli
N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide	-	Haemophilus influenzae
N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide	-	Staphylococcus aureus
N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide	-	Streptococcus pneumoniae
N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide	-	Escherichia coli
N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide	-	Haemophilus influenzae
N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide	-	Staphylococcus aureus
N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide	-	Streptococcus pneumoniae
N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide	-	Escherichia coli
N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide	-	Haemophilus influenzae
N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide	-	Staphylococcus aureus
N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide	-	Streptococcus pneumoniae
N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide	-	Escherichia coli
N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide	-	Haemophilus influenzae
N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide	-	Staphylococcus aureus
N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide	-	Streptococcus pneumoniae
N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide	-	Escherichia coli
N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide	-	Haemophilus influenzae
N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide	-	Staphylococcus aureus
N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide	-	Streptococcus pneumoniae
N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide	-	Escherichia coli
N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide	-	Haemophilus influenzae
N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide	-	Staphylococcus aureus
N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide	-	Streptococcus pneumoniae
N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide	-	Escherichia coli
N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide	-	Haemophilus influenzae
N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide	-	Staphylococcus aureus
N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide	-	Streptococcus pneumoniae
[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid	-	Escherichia coli
[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid	-	Haemophilus influenzae
[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid	-	Staphylococcus aureus
[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid	-	Streptococcus pneumoniae
[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid	-	Escherichia coli
[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid	-	Haemophilus influenzae
[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid	-	Staphylococcus aureus
[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid	-	Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.
acetyl-CoA + alpha-D-glucosamine 1-phosphate	Staphylococcus aureus	-	CoA + N-acetyl-alpha-D-glucosamine 1-phosphate	-	?
acetyl-CoA + alpha-D-glucosamine 1-phosphate	Haemophilus influenzae	-	CoA + N-acetyl-alpha-D-glucosamine 1-phosphate	-	?
acetyl-CoA + alpha-D-glucosamine 1-phosphate	Escherichia coli	-	CoA + N-acetyl-alpha-D-glucosamine 1-phosphate	-	?
acetyl-CoA + alpha-D-glucosamine 1-phosphate	Streptococcus pneumoniae	-	CoA + N-acetyl-alpha-D-glucosamine 1-phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-
Haemophilus influenzae	-	-	-
Staphylococcus aureus	-	-	-
Streptococcus pneumoniae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
acetyl-CoA + alpha-D-glucosamine 1-phosphate	-	Staphylococcus aureus	CoA + N-acetyl-alpha-D-glucosamine 1-phosphate	-	?
acetyl-CoA + alpha-D-glucosamine 1-phosphate	-	Haemophilus influenzae	CoA + N-acetyl-alpha-D-glucosamine 1-phosphate	-	?
acetyl-CoA + alpha-D-glucosamine 1-phosphate	-	Escherichia coli	CoA + N-acetyl-alpha-D-glucosamine 1-phosphate	-	?
acetyl-CoA + alpha-D-glucosamine 1-phosphate	-	Streptococcus pneumoniae	CoA + N-acetyl-alpha-D-glucosamine 1-phosphate	-	?

Subunits

Subunits	Comment	Organism
heterotrimer	-	Staphylococcus aureus
heterotrimer	-	Haemophilus influenzae
heterotrimer	-	Escherichia coli
heterotrimer	-	Streptococcus pneumoniae

Synonyms

Synonyms	Comment	Organism
GlmU	-	Staphylococcus aureus
GlmU	-	Haemophilus influenzae
GlmU	-	Escherichia coli
GlmU	-	Streptococcus pneumoniae
N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase	-	Staphylococcus aureus
N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase	-	Haemophilus influenzae
N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase	-	Escherichia coli
N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase	-	Streptococcus pneumoniae

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
22	-	assay at romm temperature	Staphylococcus aureus
22	-	assay at romm temperature	Haemophilus influenzae
22	-	assay at romm temperature	Escherichia coli
22	-	assay at romm temperature	Streptococcus pneumoniae

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.3	7.4	assay at	Staphylococcus aureus
7.3	7.4	assay at	Haemophilus influenzae
7.3	7.4	assay at	Escherichia coli
7.3	7.4	assay at	Streptococcus pneumoniae

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.00009	-	pH 7.35, 22°C	Escherichia coli	4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid
0.0001	-	pH 7.35, 22°C	Escherichia coli	[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid
0.0002	-	pH 7.35, 22°C	Haemophilus influenzae	[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid
0.0002	-	pH 7.35, 22°C	Escherichia coli	[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid
0.00025	-	pH 7.35, 22°C	Escherichia coli	4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid
0.0003	-	pH 7.35, 22°C	Haemophilus influenzae	[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid
0.0004	-	pH 7.35, 22°C	Escherichia coli	4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
0.0005	-	pH 7.35, 22°C	Escherichia coli	N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine
0.0005	-	pH 7.35, 22°C	Escherichia coli	N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine
0.0005	-	pH 7.35, 22°C	Escherichia coli	(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid
0.0005	-	pH 7.35, 22°C	Haemophilus influenzae	4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid
0.0005	-	pH 7.35, 22°C	Streptococcus pneumoniae	4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid
0.0005	-	pH 7.35, 22°C	Escherichia coli	1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid
0.0006	-	pH 7.35, 22°C	Haemophilus influenzae	4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid
0.0009	-	pH 7.35, 22°C	Escherichia coli	2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid
0.001	-	pH 7.35, 22°C	Haemophilus influenzae	N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine
0.001	-	pH 7.35, 22°C	Escherichia coli	N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide
0.001	-	pH 7.35, 22°C	Haemophilus influenzae	1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid
0.0015	-	pH 7.35, 22°C	Escherichia coli	N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide
0.002	-	pH 7.35, 22°C	Escherichia coli	N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide
0.002	-	pH 7.35, 22°C	Haemophilus influenzae	2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate
0.002	-	pH 7.35, 22°C	Escherichia coli	2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate
0.002	-	pH 7.35, 22°C	Haemophilus influenzae	(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid
0.002	-	pH 7.35, 22°C	Escherichia coli	N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide
0.002	-	pH 7.35, 22°C	Streptococcus pneumoniae	1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid
0.002	-	pH 7.35, 22°C	Streptococcus pneumoniae	4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
0.003	-	pH 7.35, 22°C	Haemophilus influenzae	N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide
0.003	-	pH 7.35, 22°C	Escherichia coli	N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide
0.003	-	pH 7.35, 22°C	Escherichia coli	4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid
0.003	-	pH 7.35, 22°C	Escherichia coli	4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
0.003	-	pH 7.35, 22°C	Haemophilus influenzae	4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
0.004	-	pH 7.35, 22°C	Escherichia coli	N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.005	-	pH 7.35, 22°C	Haemophilus influenzae	N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine
0.005	-	pH 7.35, 22°C	Escherichia coli	N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.005	-	pH 7.35, 22°C	Haemophilus influenzae	4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid
0.005	-	pH 7.35, 22°C	Streptococcus pneumoniae	4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
0.005	-	pH 7.35, 22°C	Haemophilus influenzae	2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid
0.006	-	pH 7.35, 22°C	Haemophilus influenzae	N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide
0.006	-	pH 7.35, 22°C	Haemophilus influenzae	N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide
0.006	-	pH 7.35, 22°C	Haemophilus influenzae	4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
0.008	-	pH 7.35, 22°C	Haemophilus influenzae	N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide
0.01	-	pH 7.35, 22°C	Streptococcus pneumoniae	(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid
0.01	-	pH 7.35, 22°C	Haemophilus influenzae	N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.01	-	pH 7.35, 22°C	Escherichia coli	N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide
0.01	-	pH 7.35, 22°C	Staphylococcus aureus	4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
0.012	-	pH 7.35, 22°C	Streptococcus pneumoniae	4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid
0.015	-	pH 7.35, 22°C	Escherichia coli	N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.015	-	pH 7.35, 22°C	Escherichia coli	N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.015	-	pH 7.35, 22°C	Escherichia coli	methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate
0.015	-	pH 7.35, 22°C	Streptococcus pneumoniae	2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid
0.016	-	pH 7.35, 22°C	Haemophilus influenzae	N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide
0.017	-	pH 7.35, 22°C	Escherichia coli	N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide
0.02	-	pH 7.35, 22°C	Streptococcus pneumoniae	N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine
0.02	-	pH 7.35, 22°C	Streptococcus pneumoniae	4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid
0.02	-	pH 7.35, 22°C	Escherichia coli	N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide
0.02	-	pH 7.35, 22°C	Haemophilus influenzae	N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.021	-	pH 7.35, 22°C	Escherichia coli	N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide
0.025	-	pH 7.35, 22°C	Escherichia coli	N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.03	-	pH 7.35, 22°C	Streptococcus pneumoniae	N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine
0.03	-	pH 7.35, 22°C	Haemophilus influenzae	N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.04	-	pH 7.35, 22°C	Haemophilus influenzae	N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide
0.04	-	pH 7.35, 22°C	Escherichia coli	N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide
0.047	-	pH 7.35, 22°C	Haemophilus influenzae	N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide
0.05	-	pH 7.35, 22°C	Staphylococcus aureus	1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid
0.055	-	pH 7.35, 22°C	Streptococcus pneumoniae	N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide
0.055	-	pH 7.35, 22°C	Haemophilus influenzae	methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate
0.06	-	pH 7.35, 22°C	Haemophilus influenzae	N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.07	-	pH 7.35, 22°C	Haemophilus influenzae	N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide
0.07	-	pH 7.35, 22°C	Streptococcus pneumoniae	N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide
0.08	-	pH 7.35, 22°C	Haemophilus influenzae	N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.08	-	pH 7.35, 22°C	Escherichia coli	N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide
0.08	-	pH 7.35, 22°C	Haemophilus influenzae	N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide
0.09	-	pH 7.35, 22°C	Streptococcus pneumoniae	2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate
0.1	-	pH 7.35, 22°C	Escherichia coli	N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide
0.11	-	pH 7.35, 22°C	Streptococcus pneumoniae	N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide
0.12	-	pH 7.35, 22°C	Haemophilus influenzae	N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide
0.13	-	pH 7.35, 22°C	Escherichia coli	N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Streptococcus pneumoniae	N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Streptococcus pneumoniae	N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid
0.2	-	above, pH 7.35, 22°C	Streptococcus pneumoniae	[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide
0.2	-	above, pH 7.35, 22°C	Streptococcus pneumoniae	N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid
0.2	-	above, pH 7.35, 22°C	Haemophilus influenzae	4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid
0.2	-	above, pH 7.35, 22°C	Escherichia coli	4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid
0.2	-	above, pH 7.35, 22°C	Streptococcus pneumoniae	4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide
0.2	-	above, pH 7.35, 22°C	Haemophilus influenzae	N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide
0.2	-	above, pH 7.35, 22°C	Streptococcus pneumoniae	N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide
0.2	-	above, pH 7.35, 22°C	Haemophilus influenzae	N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide
0.2	-	above, pH 7.35, 22°C	Escherichia coli	N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide
0.2	-	above, pH 7.35, 22°C	Streptococcus pneumoniae	N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Streptococcus pneumoniae	N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Streptococcus pneumoniae	N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Streptococcus pneumoniae	N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Haemophilus influenzae	N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Streptococcus pneumoniae	N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Haemophilus influenzae	N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Streptococcus pneumoniae	N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Haemophilus influenzae	N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Streptococcus pneumoniae	N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Haemophilus influenzae	N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Escherichia coli	N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Streptococcus pneumoniae	N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Streptococcus pneumoniae	N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Streptococcus pneumoniae	N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Streptococcus pneumoniae	N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Streptococcus pneumoniae	N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Streptococcus pneumoniae	N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Streptococcus pneumoniae	N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Haemophilus influenzae	N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Escherichia coli	N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Streptococcus pneumoniae	N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Streptococcus pneumoniae	N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate
0.2	-	above, pH 7.35, 22°C	Streptococcus pneumoniae	methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide
0.2	-	above, pH 7.35, 22°C	Escherichia coli	N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid
0.2	-	above, pH 7.35, 22°C	Staphylococcus aureus	[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid
0.2	-	pH 7.35, 22°C	Escherichia coli	N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide
0.54	-	pH 7.35, 22°C	Haemophilus influenzae	N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide

General Information

General Information	Comment	Organism
physiological function	the C-terminal domain of bifunctional GlmU catalyzes the transfer of an acetyl group from acetyl coenzyme A to glucosamine-1-phosphate to produce N-acetylglucosamine-1-phosphate. In the second step, the N-terminal domain of GlmU catalyzes the transfer of uridyl monophosphate from UTP to acetylglucosamine-1-phosphate to produce UDP-GlcNAc and diphosphate	Staphylococcus aureus
physiological function	the C-terminal domain of bifunctional GlmU catalyzes the transfer of an acetyl group from acetyl coenzyme A to glucosamine-1-phosphate to produce N-acetylglucosamine-1-phosphate. In the second step, the N-terminal domain of GlmU catalyzes the transfer of uridyl monophosphate from UTP to acetylglucosamine-1-phosphate to produce UDP-GlcNAc and diphosphate	Haemophilus influenzae
physiological function	the C-terminal domain of bifunctional GlmU catalyzes the transfer of an acetyl group from acetyl coenzyme A to glucosamine-1-phosphate to produce N-acetylglucosamine-1-phosphate. In the second step, the N-terminal domain of GlmU catalyzes the transfer of uridyl monophosphate from UTP to acetylglucosamine-1-phosphate to produce UDP-GlcNAc and diphosphate	Escherichia coli
physiological function	the C-terminal domain of bifunctional GlmU catalyzes the transfer of an acetyl group from acetyl coenzyme A to glucosamine-1-phosphate to produce N-acetylglucosamine-1-phosphate. In the second step, the N-terminal domain of GlmU catalyzes the transfer of uridyl monophosphate from UTP to acetylglucosamine-1-phosphate to produce UDP-GlcNAc and diphosphate	Streptococcus pneumoniae