Any feedback?
Literature summary for 2.3.1.150 extracted from
- Acetyl coenzyme A:salutaridinol-7-O-acetyltransferase from Papaver somniferum plant cell cultures (1995), J. Biol. Chem., 270, 31091-31096.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | 0.1 mM, 56% inhibition | Papaver somniferum |  |
| 8-hydroxyquinoline | 0.1 mM, 85% inhibition | Papaver somniferum | |
| Cd2+ | 1 mM, strong | Papaver somniferum | |
| codeinone | 0.5 mM, 55% inhibition | Papaver somniferum | |
| Cu2+ | 1 mM, strong | Papaver somniferum | |
| Diethyldithiocarbamic acid sodium salt | 0.05 mM, 87% inhibition | Papaver somniferum | |
| NEM | weak | Papaver somniferum | |
| p-chloromercuribenzoate | weak | Papaver somniferum | |
| salutaridine | 0.5 mM, 74% inhibition | Papaver somniferum | |
| thebaine | 0.5 mM, 76% inhibition | Papaver somniferum | |
| Zn2+ | 1 mM, strong | Papaver somniferum | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.007 | - |
salutaridinol | - |
Papaver somniferum | |
| 0.046 | - |
acetyl-CoA | - |
Papaver somniferum | |
| 0.068 | - |
n-propionyl-CoA | - |
Papaver somniferum | |
| 0.093 | - |
n-hexanoyl-CoA | - |
Papaver somniferum | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 50000 | - |
1 * 50000, SDS-PAGE | Papaver somniferum |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Acetyl-CoA + salutaridinol | Papaver somniferum | the enzyme catalyzes the formation of thebaine in morphine biosynthesis | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| no activity in Papaver rhoeas | - |
cell cultures | - |
| Papaver bracteatum | - |
- |
- |
| Papaver somniferum | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Papaver somniferum |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cell culture | - |
Papaver somniferum | - |
| cell suspension culture | - |
Papaver bracteatum | - |
| leaf | - |
Papaver somniferum | - |
| plant capsule | - |
Papaver somniferum | - |
| root | - |
Papaver somniferum | - |
| shoot | - |
Papaver somniferum | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Papaver somniferum |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Acetyl-CoA + nudaurine | - |
Papaver somniferum | ? | - |
? | |
| acetyl-CoA + salutaridinol | - |
Papaver somniferum | CoA + 7-O-acetylsalutaridinol | - |
? | |
| acetyl-CoA + salutaridinol | - |
Papaver bracteatum | CoA + 7-O-acetylsalutaridinol | - |
? | |
| Acetyl-CoA + salutaridinol | the enzyme catalyzes the formation of thebaine in morphine biosynthesis | Papaver somniferum | ? | - |
? | |
| n-Hexanoyl-CoA + salutaridinol | - |
Papaver somniferum | ? | - |
? | |
| n-Propionyl-CoA + salutaridinol | - |
Papaver somniferum | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | 1 * 50000, SDS-PAGE | Papaver somniferum |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 47 | - |
- |
Papaver somniferum |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 9 | - |
Papaver somniferum |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
