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Literature summary for 2.3.1.147 extracted from

  • Winkler, J.D.; Fonteh, A.N.; Sung, C.M.; Heravi, J.D.; Nixon, A.B.; Chabot-Fletcher, M.; Griswold, D.; Marshall, L.A.; Chilton, F.H.
    Effects of CoA-independent transacylase inhibitors on the production of lipid inflammatory mediators (1995), J. Pharmacol. Exp. Ther., 274, 1338-1347.
    View publication on PubMed
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Application

Application Comment Organism
pharmacology the enzyme may be a new therapeutic target to regulate inflammatory mediators Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-[2-[3-(4-Chloro-3-trifluoromethylphenyl)ureido]-4-trifluoromethyl phenoxy]-4,5-dichlorobenzene sulfonic acid i.e. SK&F 45905 Homo sapiens
Diethyl 7-(3,4,5-triphenyl-2-oxo-2,3-dihydro-imidazol-1-yl)heptane-phosphonate i.e. SK&F 98625 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens blockade of the enzyme, which leads to inhibition of arachidonate remodelling between phospholipids, results in the attenuation of platelet-activating factor production, arachidonic acid release and the formation of eicosanoid products ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information blockade of the enzyme, which leads to inhibition of arachidonate remodelling between phospholipids, results in the attenuation of platelet-activating factor production, arachidonic acid release and the formation of eicosanoid products Homo sapiens ?
-
 ?