Cloned (Comment) | Organism |
---|---|
gene lpxA, DNA and amino acid sequence determination, subcloning in Escherichia coli, wild-type and mutant strains expression analysis | Moraxella catarrhalis |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction and characterization of an isogenic Moraxella catarrhalis lpxA mutant in strain O35E, which is viable despite the complete loss of cell surface lipooligosaccharides, the mutant strain shows significantly decreased toxicity in the Limulus amebocyte lysate assay, reduced resistance to normal human serum, reduced adherence to human epithelial cells, and enhanced clearance in lungs and nasopharynx in a mouse aerosol challenge model, phenotype, overview, the mutant elicits high levels of antibodies with bactericidal activity and provides protection against a challenge with the wild-type strain, thus the null LOS mutant is attenuated and may be a potential vaccine candidate against Moraxella catarrhalis | Moraxella catarrhalis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Moraxella catarrhalis | the enzyme is responsible for the first step of lipid A biosynthesis | ? | - |
? | |
additional information | Moraxella catarrhalis O35E | the enzyme is responsible for the first step of lipid A biosynthesis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Moraxella catarrhalis | Q3BDJ0 | gene lpxA | - |
Moraxella catarrhalis O35E | Q3BDJ0 | gene lpxA | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is responsible for the first step of lipid A biosynthesis | Moraxella catarrhalis | ? | - |
? | |
additional information | the enzyme is responsible for the first step of lipid A biosynthesis | Moraxella catarrhalis O35E | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LpxA | - |
Moraxella catarrhalis |
UDP-N-acetylglucosamine acyltransferase | - |
Moraxella catarrhalis |