Literature summary for 2.3.1.118 extracted from

Zhang, Q.F.; Gu, J.; Gong, P.; Wang, X.D.; Tu, S.; Bi, L.J.; Yu, Z.N.; Zhang, Z.P.; Cui, Z.Q.; Wei, H.P.; Tao, S.C.; Zhang, X.E.; Deng, J.Y.
Reversibly acetylated lysine residues play important roles in the enzymatic activity of Escherichia coli N-hydroxyarylamine O-acetyltransferase (2013), FEBS J., 280, 1966-1979.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli AD494 and BL21(DE3) cells	Escherichia coli

Protein Variants

Protein Variants	Comment	Organism
G127A	mutation has no obvious effect on enzymatic activity	Escherichia coli
K214R	the mutant exhibits an about 25% decrease in enzyme activity compared to the wild type enzyme	Escherichia coli
K214R/K281R	the mutant exhibits an about 25% decrease in enzyme activity compared to the wild type enzyme	Escherichia coli
K281R	the mutant exhibits an about 12% decrease in enzyme activity compared to the wild type enzyme	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
Ni-NTA column chromatography	Escherichia coli

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + N-hydroxy-2-aminofluorene	-	Escherichia coli	CoA + N-acetyloxy-2-aminofluorene	-	?
acetyl-CoA + N-hydroxy-2-aminofluorene	-	Escherichia coli AD494	CoA + N-acetyloxy-2-aminofluorene	-	?
additional information	the enzyme is deacetylated by CobB	Escherichia coli	?	-	?
additional information	the enzyme is deacetylated by CobB	Escherichia coli AD494	?	-	?

Synonyms

Synonyms	Comment	Organism
N-hydroxyarylamine O-acetyltransferase	-	Escherichia coli
NhoA	-	Escherichia coli

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Release 2023.1 (January 2023)