Protein Variants | Comment | Organism |
---|---|---|
I238T | about 30% of wild-type activity | Homo sapiens |
K185N | about 40% of wild-type activity | Homo sapiens |
N172I | about 20% of wild-type activity | Homo sapiens |
N245I | enzymic activity comparable to wild-type, slight increase in Km-value | Homo sapiens |
W77R | about 25% of wild-type activity | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.238 | - |
2-Aminofluorene | wild-type, pH 7.2, 37°C | Homo sapiens | |
0.298 | - |
2-Aminofluorene | mutant I238T, pH 7.2, 37°C | Homo sapiens | |
0.301 | - |
2-Aminofluorene | mutant N245I, pH 7.2, 37°C | Homo sapiens | |
0.304 | - |
2-Aminofluorene | mutant W77R, pH 7.2, 37°C | Homo sapiens | |
0.367 | - |
2-Aminofluorene | mutant K185N, pH 7.2, 37°C | Homo sapiens | |
0.857 | - |
2-Aminofluorene | mutant N172I, pH 7.2, 37°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isoform NAT2 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 2-aminofluorene | - |
Homo sapiens | CoA + N-acetyl-2-aminofluorene | - |
? |