Cloned (Comment) | Organism |
---|---|
- |
Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
G134W/G136W/L139P | loss of catalytic activity | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microtubule | colocalization with microtubules | Mus musculus | 5874 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8K341 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
acetylation | enzyme catalyzes acetylation of multiple lysine residues on itself. Autoacetylation of alphaTAT1 increases its catalytic activity at microtubules | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cerebellum | - |
Mus musculus | - |
ganglion | dorsal root ganglion | Mus musculus | - |
hippocampus | - |
Mus musculus | - |
nervous system | strongest expression in nervous systems of embryonic and adult mice | Mus musculus | - |
spinal cord | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + [alpha-TAT1]-L-lysine | - |
Mus musculus | CoA + [alpha-TAT1]-N6-acetyl-L-lysine | enzyme TAT1 acetylates itself in a regulatory mechanism that is required for effective modification of tubulin. Acetylation of multiple lysine residues on itself | ? | |
acetyl-CoA + [alpha-tubulin]-L-lysine40 | - |
Mus musculus | CoA + [alpha-tubulin]-N6-acetyl-L-lysine40 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alphaTAT1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | alphaTAT1 promotes microtubule destabilization and accelerates microtubule dynamics. This effect persists in an alphaTAT1 mutant with no acetyltransferase activity, suggesting that interaction of alphaTAT1 with microtubules is the critical factor regulating microtubule stability | Mus musculus |