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Literature summary for 2.3.1.108 extracted from

  • Szyk, A.; Deaconescu, A.M.; Spector, J.; Goodman, B.; Valenstein, M.L.; Ziolkowska, N.E.; Kormendi, V.; Grigorieff, N.; Roll-Mecak, A.
    Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase (2014), Cell, 157, 1405-1415.
    View publication on PubMedView publication on EuropePMC
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Crystallization (Commentary)

Crystallization (Comment) Organism
cocrystal structures with bisubstrate analogs, consisting of a substrate peptide covalently linked to CoA through Lys40, to 1.35 A resolution. Substrate residue Lys40 is engaged in a suboptimal active site Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microtubule lumen of microtubule Homo sapiens 5874
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q5SQI0
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-

General Information

General Information Comment Organism
physiological function despite the confined intraluminal location of microtubule residue Lys40, TAT efficiently scans the microtubule bidirectionally and acetylates stochastically without preference for ends. TAT catalytic activity, not constrained luminal diffusion, is rate limiting for acetylation Homo sapiens