Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
Mec-17 | - |
Caenorhabditis elegans |
General Information | Comment | Organism |
---|---|---|
physiological function | loss of MEC-17 leads to microtubule instability, a reduction in mitochondrial number, and disrupted axonal transport, with altered distribution of both mitochondria and synaptic components. MEC-17-mediated axonal degeneration occurs independently from its acetyltransferase domain, it is enhanced by mutation of coel-1, a tubulin-associated molecule; and correlates with the animals body length | Caenorhabditis elegans |