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Literature summary for 2.3.1.1 extracted from

  • Dercksen, M.; IJlst, L.; Duran, M.; Mienie, L.J.; van Cruchten, A.; van der Westhuizen, F.H.; Wanders, R.J.
    Inhibition of N-acetylglutamate synthase by various monocarboxylic and dicarboxylic short-chain coenzyme A esters and the production of alternative glutamate esters (2014), Biochim. Biophys. Acta, 1842, 2510-2516.
    View publication on PubMed
Search for more literature for 2.3.1.1

Activating Compound

Activating Compound Comment Organism Structure
L-arginine
-
 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 AI cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3-methylcrotonyl-CoA about 45% residual activity at 2.5 mM Homo sapiens
butyryl-CoA about 30% residual activity at 2.5 mM Homo sapiens
glutaryl-CoA about 50% residual activity at 2.5 mM Homo sapiens
isobutyryl-CoA about 45% residual activity at 2.5 mM Homo sapiens
isovaleryl-CoA about 50% residual activity at 2.5 mM Homo sapiens
methylmalonyl-CoA about 40% residual activity at 2.5 mM Homo sapiens
propionyl-CoA about 20% residual activity at 2.5 mM Homo sapiens
succinyl-CoA about 60% residual activity at 2.5 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.3
-
 acetyl-CoA at pH 8.5 and 30°C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + L-glutamate Homo sapiens
-
 CoA + N-acetyl-L-glutamate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + L-glutamate
-
 Homo sapiens CoA + N-acetyl-L-glutamate
-
 ?
butyryl-CoA + L-glutamate low activity compared to acetyl-CoA Homo sapiens CoA + N-butyryl-L-glutamate
-
 ?
additional information no activity with isobutyryl-CoA, isovaleryl-CoA, 3-methylcrotonyl-CoA, methylmalonyl-CoA, succinyl-CoA, and glutaryl-CoA Homo sapiens ?
-
 ?
propionyl-CoA + L-glutamate low activity compared to acetyl-CoA Homo sapiens CoA + N-propionyl-L-glutamate
-
 ?

Synonyms

Synonyms Comment Organism
N-acetylglutamate synthase
-
 Homo sapiens
NAGS
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3
-
 butyryl-CoA at pH 8.5 and 30°C Homo sapiens
1.9
-
 isovaleryl-CoA at pH 8.5 and 30°C Homo sapiens