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Literature summary for 2.3.1.1 extracted from

  • Marvil, D.K.; Leisinger, T.
    N-Acetylglutamate synthase of Escherichia coli: purification, characterization, and molecular properties (1977), J. Biol. Chem., 252, 3295-3303.
    View publication on PubMed

General Stability

General Stability Organism
glycerol stabilizes Escherichia coli
L-arginine or N-acetyl-L-glutamate stabilizes the high molecular weight form of 300000 Da Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
arginine 0.02 mM, 50% inhibition; L-arginine Escherichia coli
Cd2+ 0.1 mM, 94% inhibition Escherichia coli
coenzyme A 2.5 mM, 50% inhibition Escherichia coli
Cu2+ 0.1 mM, 68% inhibition Escherichia coli
Hg2+ 0.1 mM; 50% inhibition Escherichia coli
high ionic strength
-
Escherichia coli
KCl 100 mM, 36% inhibition after 1 h, 300 mM, 74% inhibition after 1 h, 500 mM, 87% inhibition after 1 h Escherichia coli
L-citrulline 10 mM, 75% inhibition Escherichia coli
N-acetylglutamate 25 mM, 50% inhibition Escherichia coli
N-ethylmaleimide
-
Escherichia coli
p-chloromercuribenzoate
-
Escherichia coli
p-hydroxymercuribenzoate
-
Escherichia coli
Zn2+ 0.1 mM, 43% inhibition Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
51700
-
6 * 51700, SDS-PAGE, cross-linking studies with dimethylsuberimidate, in the maximally aggregated state the enzyme exists as a hexamer Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
DEAE-cellulose, hydroxylapatite Escherichia coli

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
133
-
-
Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + L-glutamate
-
Escherichia coli CoA + N-acetyl-L-glutamate
-
?

Subunits

Subunits Comment Organism
hexamer 6 * 51700, SDS-PAGE, cross-linking studies with dimethylsuberimidate, in the maximally aggregated state the enzyme exists as a hexamer Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
10
-
-
Escherichia coli

pH Stability

pH Stability pH Stability Maximum Comment Organism
7
-
highest stability Escherichia coli