Literature summary for 2.3.1.1 extracted from

Abadjieva, A.; Pauwels, K.; Hilven, P.; Crabeel, M.
A new yeast metabolon involving at least the two first enzymes of arginine biosynthesis. Acetylglutamate synthase activity requires complex formation with acetylglutamate kinase (2001), J. Biol. Chem., 276, 42869-42880.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	enzyme must interact stoichoimetrically in vivo with acetylglutamate kinase to be active	Saccharomyces cerevisiae

Cloned(Commentary)

Cloned (Comment)	Organism
coexpression of N-acetylglutamate synthase gene ARG2 together with ARG5 and ARG6 coding for acetylglutamate kinase and acetylglutamyl-phosphate reductase in Saccharomyces cerevisiae	Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
acetyl-CoA + L-glutamate	Saccharomyces cerevisiae	enzyme catalyzes the first step in arginine biosynthesis	CoA + N-acetyl-L-glutamate	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + L-glutamate	-	Saccharomyces cerevisiae	CoA + N-acetyl-L-glutamate	-	?
acetyl-CoA + L-glutamate	enzyme catalyzes the first step in arginine biosynthesis	Saccharomyces cerevisiae	CoA + N-acetyl-L-glutamate	-	?

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Release 2023.1 (January 2023)