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Literature summary for 2.2.1.6 extracted from
- Isobutanol production in engineered Saccharomyces cerevisiae by overexpression of 2-ketoisovalerate decarboxylase and valine biosynthetic enzymes (2012), Bioprocess Biosyst. Eng., 35, 1467-1475.
Application
| Application | Comment | Organism |
|---|---|---|
| synthesis | construction of isobutanol production systems by overexpression of effective 2-oxoacid decarboxylase KivD and combinatorial overexpression of valine biosynthetic enzymes in Saccharomyces cerevisiae D452-2. Isobutanol production by the engineered strain is assessed in micro-aerobic batch fermentations using glucose as a sole carbon source, leading to production of 93 mg/l isobutanol, which corresponds to a fourfold improvement as compared with the control strain. Isobutanol production is further enhanced to 151 mg/l by additional overexpression of acetolactate synthase Ilv2p, acetohydroxyacid reductoisomerase Ilv5p, and dihydroxyacid dehydratase Ilv3p in the cytosol | Saccharomyces cerevisiae |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | P07342 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Ilv2 | - |
Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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