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Literature summary for 2.2.1.6 extracted from

  • Kingsbury, J.M.; McCusker, J.H.
    Cytocidal amino acid starvation of Saccharomyces cerevisiae and Candida albicans acetolactate synthase (ilv2{Delta}) mutants is influenced by the carbon source and rapamycin (2009), Microbiology, 156, 929-939.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Candida albicans
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Saccharomyces cerevisiae
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General Information

General Information Comment Organism
physiological function deletion of gene ilv2 encoding acetolactate synthase results in loss of viability during isoleucine and valine starvation due to 2-oxobutanoate accumulation. Rapamycin further decreases vialbility of the mutant. Recovery from starvation is influenced by the carbon source present during recovery Saccharomyces cerevisiae
physiological function deletion of gene ilv2 encoding acetolactate synthase results in significant attenuation of virulence and a grater than 100fold reduction in viability after only four hours of isoleucine and valine starvation due to 2-oxobutanoate accumulation. Rapamycin increases vialbility of both ilv1 and ilv2 mutants. Recovery from starvation is influenced by the carbon source present during starvation Candida albicans