Literature summary for 2.2.1.6 extracted from

Wada, M.; Hijikata, N.; Aoki, R.; Takesue, N.; Yokota, A.
Enhanced valine production in Corynebacterium glutamicum with defective H+-ATPase and C-terminal truncated acetohydroxyacid synthase (2008), Biosci. Biotechnol. Biochem., 72, 2959-2965.

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Application

Application	Comment	Organism
synthesis	transformation of a H+-ATPase defective strain with a C-terminal truncation of acetohydroxyacid synthase gene ilvBN results in increased valine production from 21.7 mM for wild-type to 46.7 mM and increase in the valine intermediate acetoin. Inserting acetohydroxyacid isomeroreductase gene into the ilvBN plasmid further increases valine producion	Corynebacterium glutamicum

Organism

Organism	UniProt	Comment	Textmining
Corynebacterium glutamicum	-	-	-

General Information

General Information	Comment	Organism
physiological function	transformation of a H+-ATPase defective strain with a C-terminal truncation of acetohydroxyacid synthase gene ilvBN results in increased valine production from 21.7 mM for wild-type to 46.7 mM and increase in the valine intermediate acetoin. Inserting acetohydroxyacid isomeroreductase gene into the ilvBN plasmid further increases valine producion	Corynebacterium glutamicum

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Release 2023.1 (January 2023)