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Literature summary for 2.2.1.2 extracted from

  • Huang, J.B.; Espinoza, J.; Romero, R.; Petty, H.R.
    Transaldolase is part of a supramolecular complex containing glucose-6-phosphate dehydrogenase in human neutrophils that undergoes retrograde trafficking during pregnancy (2005), Metab. Clin. Exp., 54, 1027-1033.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is part of a supramolecular complex containing glucose-6-phosphate dehydrogenase, responsible for substrate channeling, in female neutrophils that undergoes retrograde trafficking during pregnancy, trafficking occurs in nonpregnant women, the key regulatory enzyme in the nonoxidative branch of the hexose monophosphate shunt, is not in close physical proximity with lactate dehydrogenase, TALase’s retrograde motion contributes to uncoupling the shunt from its source of glucose-6-phosphate at the plasma membrane, thereby blunting NADPH2 production and downstream oxidant production by neutrophils, overview ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Homo sapiens
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pregnant and nonpregnant women
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Source Tissue

Source Tissue Comment Organism Textmining
neutrophil in neutrophils from nonpregnant individuals, enzyme undergoes anterograde trafficking, whereas retrograde trafficking is found during pregnacy. Trafficking involves microtubules Homo sapiens
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neutrophil the transaldolase is part of a supramolecular complex containing glucose-6-phosphate dehydrogenase in neutrophils that undergoes retrograde trafficking during pregnancy, enzyme trafficking, overview Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is part of a supramolecular complex containing glucose-6-phosphate dehydrogenase, responsible for substrate channeling, in female neutrophils that undergoes retrograde trafficking during pregnancy, trafficking occurs in nonpregnant women, the key regulatory enzyme in the nonoxidative branch of the hexose monophosphate shunt, is not in close physical proximity with lactate dehydrogenase, TALase’s retrograde motion contributes to uncoupling the shunt from its source of glucose-6-phosphate at the plasma membrane, thereby blunting NADPH2 production and downstream oxidant production by neutrophils, overview Homo sapiens ?
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?

Subunits

Subunits Comment Organism
More enzyme forms a complex with glucose-6-phosphate dehydrogenase Homo sapiens

Synonyms

Synonyms Comment Organism
TALase
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Homo sapiens
transaldolase
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Homo sapiens