Application | Comment | Organism |
---|---|---|
medicine | enzyme inhibition sensitizes cancer cells to sorafenib treatment | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate | Homo sapiens | - |
D-ribose 5-phosphate + D-xylulose 5-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocellular carcinoma cell | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate | - |
Homo sapiens | D-ribose 5-phosphate + D-xylulose 5-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TKT | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | enzyme overexpression in cancer cells is a response of Nuclear Factor, Erythroid 2-Like 2 activation | up |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme knockdown suppresses HCC cell proliferation by inducing reactive eoxygen species accumulation and reactive oxygen species-associated cell-cycle delay | Homo sapiens |
physiological function | the enzyme is required for cancer growth because of its ability to affect the production of NAPDH to counteract oxidative stress. Overexpression of the enzyme is also closely associated with aggressive clinicopathological hepatocellular carcinoma cell features, including the presence of venous invasion and tumor microsatellite formation, increased tumor size, and absence of tumor encapsulation | Homo sapiens |