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Literature summary for 2.2.1.1 extracted from

  • Xu, I.M.; Lai, R.K.; Lin, S.H.; Tse, A.P.; Chiu, D.K.; Koh, H.Y.; Law, C.T.; Wong, C.M.; Cai, Z.; Wong, C.C.; Ng, I.O.
    Transketolase counteracts oxidative stress to drive cancer development (2016), Proc. Natl. Acad. Sci. USA, 113, 725-734.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine enzyme inhibition sensitizes cancer cells to sorafenib treatment Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate Homo sapiens
-
D-ribose 5-phosphate + D-xylulose 5-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocellular carcinoma cell
-
Homo sapiens
-
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
-
Homo sapiens D-ribose 5-phosphate + D-xylulose 5-phosphate
-
?

Synonyms

Synonyms Comment Organism
TKT
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enzyme overexpression in cancer cells is a response of Nuclear Factor, Erythroid 2-Like 2 activation up

General Information

General Information Comment Organism
malfunction enzyme knockdown suppresses HCC cell proliferation by inducing reactive eoxygen species accumulation and reactive oxygen species-associated cell-cycle delay Homo sapiens
physiological function the enzyme is required for cancer growth because of its ability to affect the production of NAPDH to counteract oxidative stress. Overexpression of the enzyme is also closely associated with aggressive clinicopathological hepatocellular carcinoma cell features, including the presence of venous invasion and tumor microsatellite formation, increased tumor size, and absence of tumor encapsulation Homo sapiens