Crystallization (Comment) | Organism |
---|---|
modeling of inhibitors 1-(3-chloro-2-methylphenyl)-3-(2-hydroxy-5-nitrophenyl)urea, 1-(5-hydroxynaphthalen-1-yl)-3-(2-methyl-5-nitrophenyl)urea, 1-(5-chloro-2-hydroxy-4-nitrophenyl)-3-phenylurea into enzyme structure model. the binding mode of the compounds involves interactions with the alpha helix sequence D200-G210 interfering likely with the enzyme dimerization | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(3-chloro-2-methylphenyl)-3-(2-hydroxy-5-nitrophenyl)urea | inhibitor designed to cover a hot spot in the dimerization interface of the homodimer of the enzyme | Homo sapiens | |
1-(5-chloro-2-hydroxy-4-nitrophenyl)-3-phenylurea | inhibitor designed to cover a hot spot in the dimerization interface of the homodimer of the enzyme | Homo sapiens | |
1-(5-hydroxynaphthalen-1-yl)-3-(2-methyl-5-nitrophenyl)urea | inhibitor designed to cover a hot spot in the dimerization interface of the homodimer of the enzyme | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P29401 | - |
- |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.1 | - |
pH 7.6, 37°C | Homo sapiens | 1-(5-chloro-2-hydroxy-4-nitrophenyl)-3-phenylurea | |
0.15 | - |
pH 7.6, 37°C | Homo sapiens | 1-(5-hydroxynaphthalen-1-yl)-3-(2-methyl-5-nitrophenyl)urea | |
0.2 | - |
pH 7.6, 37°C | Homo sapiens | 1-(3-chloro-2-methylphenyl)-3-(2-hydroxy-5-nitrophenyl)urea |