Literature summary for 2.2.1.1 extracted from

Foeldi, M.; Stickeler, E.; Bau, L.; Kretz, O.; Watermann, D.; Gitsch, G.; Kayser, G.; Zur Hausen, A.; Coy, J.F.
Transketolase protein TKTL1 overexpression: A potential biomarker and therapeutic target in breast cancer (2007), Oncol. Rep., 17, 841-845.

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Application

Application	Comment	Organism
medicine	marked subset of breast cancers show a TKTL1 overexpression which correlates significantly with Her2/neu overexpression. In contrast to colon and urothelial cancer from previous studies, TKTL1 overexpression is not associated with a poor patient outcome in the examined study population. TKTL1 represents a novel metabolic biomarker in breast cancer, and a possible future target for mechanism-driven drug development	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast	only 29% of non-neoplastic breast tissues are TKTL1 immunopositive, including 9% with high expression levels	Homo sapiens	-
breast cancer cell	TKTL1 expression in 86% of breast cancer specimens with 45% showing high expression levels	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
TKTL1	-	Homo sapiens
transketolase-like-1-gene	-	Homo sapiens

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Release 2023.1 (January 2023)