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Literature summary for 2.2.1.1 extracted from

  • Joshi, S.; Singh, A.R.; Kumar, A.; Misra, P.C.; Siddiqi, M.I.; Saxena, J.K.
    Molecular cloning and characterization of Plasmodium falciparum transketolase (2008), Mol. Biochem. Parasitol., 160, 32-41.
    View publication on PubMed

Application

Application Comment Organism
drug development Plasmodium falciparum transketolase shows low homology with the host enzyme, thus may serve as a novel and promising target for designing inhibitors with anti-malarial activity Plasmodium falciparum

Cloned(Commentary)

Cloned (Comment) Organism
overexpressed in Escherichia coli BL21(DE3)Rosetta cells Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
p-hydroxyphenylpyruvate potent inhibitor when hydroxypyruvate is used as a substrate, whereas noncompetitive inhibition with fructose-6-phosphate Plasmodium falciparum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.25
-
fructose-6-phosphate
-
Plasmodium falciparum
4.78
-
Hydroxypyruvate
-
Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Plasmodium falciparum 5829
-
nucleus
-
Plasmodium falciparum 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Plasmodium falciparum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
70000
-
6 * 70000, SDS-PAGE Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
clone NF54
-

Purification (Commentary)

Purification (Comment) Organism
on Ni2+-NTA resin and by ammonium sulfate precipitation Plasmodium falciparum

Source Tissue

Source Tissue Comment Organism Textmining
additional information late trophozoite stage Plasmodium falciparum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fructose-6-phosphate + hydroxypyruvate
-
Plasmodium falciparum ?
-
?

Subunits

Subunits Comment Organism
hexamer 6 * 70000, SDS-PAGE Plasmodium falciparum

Cofactor

Cofactor Comment Organism Structure
thiamine diphosphate
-
Plasmodium falciparum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.305
-
p-hydroxyphenylpyruvate with hydroxypyruvate as substrate Plasmodium falciparum