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Literature summary for 2.2.1.1 extracted from

  • Zhang, S.; Yue, J.X.; Yang, J.H.; Cai, P.C.; Kong, W.J.
    Overexpression of transketolase protein TKTL1 is associated with occurrence and progression in nasopharyngeal carcinoma: a potential therapeutic target in nasopharyngeal carcinoma (2008), Cancer Biol. Ther., 7, 517-522.
    View publication on PubMed
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Application

Application Comment Organism
medicine TKTL1 gene influences total transketolase activity and cell proliferation in human nasopharyngeal carcinoma cells, suggesting that TKTL1 gene plays an important role on glycometabolism in tumors and may become a novel target for tumor gene therapy Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
TKTL1 cloned into vector pEGFP-C1-U6 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
RNAi inhibits expression of TKTL1, whereas total transketolase activity is dramatically downregulated and proliferation of cancer cells is significantly inhibited in CNE cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P51854
-
-
Homo sapiens Q9H0I9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information in human nasopharyngeal carcinoma tissues, TKT and TKTL2 are not upregulated Homo sapiens
-
nasopharyngeal carcinoma cell transketolase activity is significantly higher in nasopharyngeal carcinoma tissues than in chronic nasopharyngitis tissues. TKTL1 in human nasopharyngeal carcinoma tissues is upregulated, whereas TKT is not upregulated Homo sapiens
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Synonyms

Synonyms Comment Organism
TKT
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 Homo sapiens
TKTL1
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 Homo sapiens
TKTL2
-
 Homo sapiens
transketolase-like-1
-
 Homo sapiens
transketolase-like-2
-
 Homo sapiens