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Literature summary for 2.1.4.1 extracted from

  • Humm, A.; Fritsche, E.; Steinbacher, S.; Huber, R.
    Crystal structure and mechanism of human L-arginine:glycine amidinotransferase: a mitochondrial enzyme involved in creatine biosynthesis (1997), EMBO J., 16, 3373-3385.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
thyroxine induces enzyme expression Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
cDNA, nucleotide sequence determined, cloned and expressed in Escherichia coli BL21(DE3)-pLysS Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
recombinant human enzyme, bipyramidal, tetragonal crystals, belonging to space group P4(3)2(1)2, lattice constants a = b = 83.6 A, c = 200.4 A and alpha = beta = gamma = 90° Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Creatine represses enzyme expression Homo sapiens
ornithine
-
Homo sapiens
ornithine
-
Rattus norvegicus
ornithine
-
Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-
mitochondrial inner membrane
-
Homo sapiens 5743
-
mitochondrial inner membrane
-
Rattus norvegicus 5743
-
mitochondrial intermembrane space
-
Homo sapiens 5758
-
mitochondrion
-
Sus scrofa 5739
-
mitochondrion
-
Homo sapiens 5739
-
mitochondrion
-
Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arginine + glycine Homo sapiens
-
L-ornithine + guanidinoacetate
-
r
L-arginine + glycine Rattus norvegicus
-
L-ornithine + guanidinoacetate
-
r
L-arginine + glycine Sus scrofa
-
L-ornithine + guanidinoacetate
-
r
L-arginine + glycine Homo sapiens first reaction in the de novo biosynthesis of creatine L-ornithine + guanidinoacetate
-
r
L-arginine + glycine Rattus norvegicus first reaction in the de novo biosynthesis of creatine L-ornithine + guanidinoacetate
-
r
L-ornithine + guanidinoacetate Sus scrofa
-
L-arginine + glycine
-
r
L-ornithine + guanidinoacetate Homo sapiens
-
L-arginine + glycine
-
r
L-ornithine + guanidinoacetate Rattus norvegicus
-
L-arginine + glycine
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
human
-
Homo sapiens P50440 mitochondrial enzyme, DDBJ/EMBL/GenBank database, cDNA sequence
-
Homo sapiens P50440 cytosolic enzyme, DDBJ/EMBL/GenBank database, cDNA sequence
-
Rattus norvegicus
-
rat
-
Rattus norvegicus P50442 cDNA sequence, EMBL accession number
-
Sus scrofa
-
pig, porcine, hog
-

Purification (Commentary)

Purification (Comment) Organism
-
Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Sus scrofa
-
heart
-
Homo sapiens
-
muscle
-
Sus scrofa
-
muscle
-
Homo sapiens
-
muscle
-
Rattus norvegicus
-
neuron
-
Homo sapiens
-
photoreceptor
-
Homo sapiens
-
semen
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
canavanine + ornithine
-
Homo sapiens arginine + canaline
-
r
canavanine + ornithine
-
Rattus norvegicus arginine + canaline
-
r
canavanine + ornithine
-
Sus scrofa arginine + canaline
-
r
L-arginine + glycine
-
Homo sapiens L-ornithine + guanidinoacetate
-
r
L-arginine + glycine
-
Rattus norvegicus L-ornithine + guanidinoacetate
-
r
L-arginine + glycine
-
Sus scrofa L-ornithine + guanidinoacetate
-
r
L-arginine + glycine first reaction in the de novo biosynthesis of creatine Homo sapiens L-ornithine + guanidinoacetate
-
r
L-arginine + glycine first reaction in the de novo biosynthesis of creatine Rattus norvegicus L-ornithine + guanidinoacetate
-
r
L-ornithine + guanidinoacetate
-
Sus scrofa L-arginine + glycine
-
r
L-ornithine + guanidinoacetate
-
Homo sapiens L-arginine + glycine
-
r
L-ornithine + guanidinoacetate
-
Rattus norvegicus L-arginine + glycine
-
r

Subunits

Subunits Comment Organism
dimer
-
Homo sapiens
dimer
-
Rattus norvegicus
dimer
-
Sus scrofa
monomer
-
Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.253
-
ornithine
-
Homo sapiens
0.253
-
ornithine
-
Rattus norvegicus