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Literature summary for 2.1.4.1 extracted from

  • Humm, A.; Fritsche, E.; Mann, K.; Goehl, M.; Huber, R.
    Recombinant expression and isolation of human L-arginine:glycine amidinotransferase and identification of its active-site cysteine residue (1997), Biochem. J., 322, 771-776.
No PubMed abstract available
Search for more literature for 2.1.4.1

Cloned(Commentary)

Cloned (Comment) Organism
cDNA, nucleotide sequence determined, cloned and expressed in Escherichia coli BL21(DE3)-pLysS Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Creatine represses enzyme expression Homo sapiens
HCO3-
-
 Homo sapiens
Hg2+
-
 Homo sapiens
Ni2+
-
 Homo sapiens
ornithine
-
 Homo sapiens
ornithine
-
 Sus scrofa
Zn2+
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
cytosol
-
 Homo sapiens 5829
-
mitochondrial intermembrane space
-
 Homo sapiens 5758
-
mitochondrion
-
 Sus scrofa 5739
-
mitochondrion
-
 Homo sapiens 5739
-
mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arginine + glycine Homo sapiens
-
 L-ornithine + guanidinoacetate
-
 r
L-arginine + glycine Sus scrofa
-
 L-ornithine + guanidinoacetate
-
 r
L-arginine + glycine Homo sapiens first reaction in the de novo biosynthesis of creatine L-ornithine + guanidinoacetate
-
 r
L-arginine + glycine Rattus norvegicus first reaction in the de novo biosynthesis of creatine L-ornithine + guanidinoacetate
-
 r
L-ornithine + guanidinoacetate Sus scrofa
-
 L-arginine + glycine
-
 r
L-ornithine + guanidinoacetate Homo sapiens
-
 L-arginine + glycine
-
 r
L-ornithine + guanidinoacetate Rattus norvegicus
-
 L-arginine + glycine
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-
Homo sapiens P50440 mitochondrial enzyme, DDBJ/EMBL/GenBank database, cDNA sequence
-
Homo sapiens P50440 cytosolic enzyme, DDBJ/EMBL/GenBank database, cDNA sequence
-
Rattus norvegicus P50442 cDNA sequence, EMBL accession number
-
Sus scrofa
-
 pig, porcine, hog
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Sus scrofa
-
kidney
-
 Homo sapiens
-
kidney
-
 Rattus norvegicus
-
liver
-
 Sus scrofa
-
liver
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-
muscle
-
 Sus scrofa
-
muscle
-
 Homo sapiens
-
muscle
-
 Rattus norvegicus
-
neuron
-
 Homo sapiens
-
pancreas
-
 Sus scrofa
-
pancreas
-
 Homo sapiens
-
pancreas
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
23.33
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
canavanine + ornithine
-
 Homo sapiens arginine + canaline
-
 r
canavanine + ornithine
-
 Sus scrofa arginine + canaline
-
 r
canavanine + ornithine
-
 Rattus norvegicus arginine + canaline
-
 r
L-arginine + glycine
-
 Homo sapiens L-ornithine + guanidinoacetate
-
 r
L-arginine + glycine
-
 Sus scrofa L-ornithine + guanidinoacetate
-
 r
L-arginine + glycine first reaction in the de novo biosynthesis of creatine Homo sapiens L-ornithine + guanidinoacetate
-
 r
L-arginine + glycine first reaction in the de novo biosynthesis of creatine Rattus norvegicus L-ornithine + guanidinoacetate
-
 r
L-ornithine + guanidinoacetate
-
 Sus scrofa L-arginine + glycine
-
 r
L-ornithine + guanidinoacetate
-
 Homo sapiens L-arginine + glycine
-
 r
L-ornithine + guanidinoacetate
-
 Rattus norvegicus L-arginine + glycine
-
 r