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Literature summary for 2.1.3.2 extracted from

  • Vitali, J.; Vorobyova, T.; Webster, G.; Kantrowitz, E.R.
    Crystallization and structure determination of the catalytic trimer of Methanococcus jannaschii aspartate transcarbamoylase (2000), Acta Crystallogr. Sect. D, 56, 1061-1063.
    View publication on PubMed
Search for more literature for 2.1.3.2

Crystallization (Commentary)

Crystallization (Comment) Organism
crystals are grown at 295 K by the sitting-drop method from reservoirs containing 2.0 M ammonium sulfate and 5% 2-propanol. The catalytic trimer is crystallized in space group R32, with unit-cell parameters a = b = 265.3, c = 195.5 A and two trimers in the asymmetric unit. Its structure is determined using molecular replacement and Patterson methods Methanocaldococcus jannaschii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
carbamoyl phosphate + L-aspartate Methanocaldococcus jannaschii the enzyme catalyzes the first step in the pyrimidine biosynthetic pathway phosphate + N-carbamoyl-L-aspartate
-
 ?
carbamoyl phosphate + L-aspartate Methanocaldococcus jannaschii DSM 2661 the enzyme catalyzes the first step in the pyrimidine biosynthetic pathway phosphate + N-carbamoyl-L-aspartate
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 ?

Organism

Organism UniProt Comment Textmining
Methanocaldococcus jannaschii Q58976
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Methanocaldococcus jannaschii DSM 2661 Q58976
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
carbamoyl phosphate + L-aspartate
-
 Methanocaldococcus jannaschii phosphate + N-carbamoyl-L-aspartate
-
 ?
carbamoyl phosphate + L-aspartate the enzyme catalyzes the first step in the pyrimidine biosynthetic pathway Methanocaldococcus jannaschii phosphate + N-carbamoyl-L-aspartate
-
 ?
carbamoyl phosphate + L-aspartate
-
 Methanocaldococcus jannaschii DSM 2661 phosphate + N-carbamoyl-L-aspartate
-
 ?
carbamoyl phosphate + L-aspartate the enzyme catalyzes the first step in the pyrimidine biosynthetic pathway Methanocaldococcus jannaschii DSM 2661 phosphate + N-carbamoyl-L-aspartate
-
 ?

Subunits

Subunits Comment Organism
trimer
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 Methanocaldococcus jannaschii

Synonyms

Synonyms Comment Organism
aspartate transcarbamoylase
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 Methanocaldococcus jannaschii
ATCase
-
 Methanocaldococcus jannaschii

General Information

General Information Comment Organism
physiological function the enzyme catalyzes the first step in the pyrimidine biosynthetic pathway Methanocaldococcus jannaschii