Cloned (Comment) | Organism |
---|---|
coexpression of carbamoylphosphate synthetase II, aspartate transcarbamoylase, and dihydroorotase in Escherichia coli | Trypanosoma cruzi |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Trypanosoma cruzi | direct intermolecular interactions between the enzymes catalyzing the first three reaction steps of the de novo pyrimidine biosynthetic pathway, carbamoylphosphate synthetase II (CPSII), aspartate transcarbamoylase (ATC), and dihydroorotase (DHO), of the parasitic protist Trypanosoma cruzi, interaction analysis, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma cruzi | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | direct intermolecular interactions between the enzymes catalyzing the first three reaction steps of the de novo pyrimidine biosynthetic pathway, carbamoylphosphate synthetase II (CPSII), aspartate transcarbamoylase (ATC), and dihydroorotase (DHO), of the parasitic protist Trypanosoma cruzi, interaction analysis, overview | Trypanosoma cruzi | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aspartate transcarbamoylase | - |
Trypanosoma cruzi |
ATC | - |
Trypanosoma cruzi |
General Information | Comment | Organism |
---|---|---|
evolution | 2 types of the enzyme occur: a CPSII-DHO-ATC fusion enzyme (CAD) found in animals, fungi, and amoebozoa, where the enzymes carbamoylphosphate synthetase II (CPSII), aspartate transcarbamoylase (ATC), and dihydroorotase (DHO), catalyzing the first three reaction steps of the de novo pyrimidine biosynthetic pathway, form a complex, and (2) stand-alone enzymes found in plants and the protist groups | Trypanosoma cruzi |