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Literature summary for 2.1.2.3 extracted from

  • Boccalatte, F.E.; Voena, C.; Riganti, C.; Bosia, A.; DAmico, L.; Riera, L.; Cheng, M.; Ruggeri, B.; Jensen, O.N.; Goss, V.L.; Lee, K.; Nardone, J.; Rush, J.; Polakiewicz, R.D.; Comb, M.J.; Chiarle, R.; Inghirami, G.
    The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL (2009), Blood, 113, 2776-2790.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
additional information enzyme phosphorylation by anaplastic lymphoma kinase enhances enzymatic activity and dampens the methotrexate-mediated transformylase activity inhibition Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
methotrexate enzyme phosphorylation dampens the methotrexate-mediated transformylase activity inhibition Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P31939 bifunctional 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein bifunctional 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase associates with nucleoplasmin-anaplastic lymphoma kinase, and its phosphorylation requires anaplastic lymphoma kinase activity. Phosphorylation enhances enzymatic activity and dampens the methotrexate-mediated transformylase activity inhibition Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
CCRF-CEM cell
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 Homo sapiens
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JURKAT cell
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 Homo sapiens
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Mac-1 cell
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 Homo sapiens
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SUP-M2 cell
-
 Homo sapiens
-
Sup-M2-TS cell
-
 Homo sapiens
-