Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | enzyme phosphorylation by anaplastic lymphoma kinase enhances enzymatic activity and dampens the methotrexate-mediated transformylase activity inhibition | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
methotrexate | enzyme phosphorylation dampens the methotrexate-mediated transformylase activity inhibition | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P31939 | bifunctional 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | bifunctional 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase associates with nucleoplasmin-anaplastic lymphoma kinase, and its phosphorylation requires anaplastic lymphoma kinase activity. Phosphorylation enhances enzymatic activity and dampens the methotrexate-mediated transformylase activity inhibition | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CCRF-CEM cell | - |
Homo sapiens | - |
JURKAT cell | - |
Homo sapiens | - |
Mac-1 cell | - |
Homo sapiens | - |
SUP-M2 cell | - |
Homo sapiens | - |
Sup-M2-TS cell | - |
Homo sapiens | - |