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Literature summary for 2.1.2.3 extracted from

  • Li, C.; Xu, L.; Wolan, D.W.; Wilson, I.A.; Olson, A.J.
    Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors (2004), J. Med. Chem., 47, 6681-6690.
    View publication on PubMed

Application

Application Comment Organism
medicine potential target for antineoplastic drug design Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
NSC126445 IC50: 0.010mM Homo sapiens
NSC170645 IC50: 0.036 mM Homo sapiens
NSC26699 IC50: 0.017 mM Homo sapiens
NSC292213 IC50: 0.009 mM Homo sapiens
NSC30171 IC50: 0.0006 mM Homo sapiens
NSC321237 IC50: 0.106 mM Homo sapiens
NSC324571 IC50: 0.020 mM Homo sapiens
NSC324572 IC50: 0.012 mM Homo sapiens
NSC324981 IC50: 0.020 mM Homo sapiens
NSC326203 IC50: 0.012 mM Homo sapiens
NSC326211 IC50: 0.204 mM Homo sapiens
NSC37031 IC50: 0.008 mM Homo sapiens
NSC37173 IC50: 0.004 mM Homo sapiens
NSC41806 IC50: 0.055 mM Homo sapiens
NSC45592 IC50: 0.012 mM Homo sapiens
NSC47729 IC50: 0.003 mM Homo sapiens
NSC58046 IC50: 0.008 mM Homo sapiens
NSC7524 IC50: 0.231 mM Homo sapiens
NSC88915 IC50: 0.014 mM Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazole-4-carboxamide Homo sapiens penultimate step of the purine de novo synthesis pathway tetrahydrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazole-4-carboxamide
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P31939
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazole-4-carboxamide
-
Homo sapiens tetrahydrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazole-4-carboxamide
-
?
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazole-4-carboxamide penultimate step of the purine de novo synthesis pathway Homo sapiens tetrahydrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazole-4-carboxamide
-
?

Synonyms

Synonyms Comment Organism
AICAR transformylase/inosine monophosphate cyclohydrolase bifunctional enzyme catalyzing the last two steps of the purine de novo synthesis pathway Homo sapiens

Cofactor

Cofactor Comment Organism Structure
10-formyltetrahydrofolate
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000015
-
NSC30171
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0006
-
IC50: 0.0006 mM Homo sapiens NSC30171
0.003
-
IC50: 0.003 mM Homo sapiens NSC47729
0.004
-
IC50: 0.004 mM Homo sapiens NSC37173
0.008
-
IC50: 0.008 mM Homo sapiens NSC37031
0.008
-
IC50: 0.008 mM Homo sapiens NSC58046
0.009
-
IC50: 0.009 mM Homo sapiens NSC292213
0.01
-
IC50: 0.010mM Homo sapiens NSC126445
0.012
-
IC50: 0.012 mM Homo sapiens NSC326203
0.012
-
IC50: 0.012 mM Homo sapiens NSC45592
0.012
-
IC50: 0.012 mM Homo sapiens NSC324572
0.014
-
IC50: 0.014 mM Homo sapiens NSC88915
0.017
-
IC50: 0.017 mM Homo sapiens NSC26699
0.02
-
IC50: 0.020 mM Homo sapiens NSC324981
0.02
-
IC50: 0.020 mM Homo sapiens NSC324571
0.036
-
IC50: 0.036 mM Homo sapiens NSC170645
0.055
-
IC50: 0.055 mM Homo sapiens NSC41806
0.106
-
IC50: 0.106 mM Homo sapiens NSC321237
0.204
-
IC50: 0.204 mM Homo sapiens NSC326211
0.231
-
IC50: 0.231 mM Homo sapiens NSC7524