Application | Comment | Organism |
---|---|---|
medicine | potential target for antineoplastic drug design | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
NSC126445 | IC50: 0.010mM | Homo sapiens | |
NSC170645 | IC50: 0.036 mM | Homo sapiens | |
NSC26699 | IC50: 0.017 mM | Homo sapiens | |
NSC292213 | IC50: 0.009 mM | Homo sapiens | |
NSC30171 | IC50: 0.0006 mM | Homo sapiens | |
NSC321237 | IC50: 0.106 mM | Homo sapiens | |
NSC324571 | IC50: 0.020 mM | Homo sapiens | |
NSC324572 | IC50: 0.012 mM | Homo sapiens | |
NSC324981 | IC50: 0.020 mM | Homo sapiens | |
NSC326203 | IC50: 0.012 mM | Homo sapiens | |
NSC326211 | IC50: 0.204 mM | Homo sapiens | |
NSC37031 | IC50: 0.008 mM | Homo sapiens | |
NSC37173 | IC50: 0.004 mM | Homo sapiens | |
NSC41806 | IC50: 0.055 mM | Homo sapiens | |
NSC45592 | IC50: 0.012 mM | Homo sapiens | |
NSC47729 | IC50: 0.003 mM | Homo sapiens | |
NSC58046 | IC50: 0.008 mM | Homo sapiens | |
NSC7524 | IC50: 0.231 mM | Homo sapiens | |
NSC88915 | IC50: 0.014 mM | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazole-4-carboxamide | Homo sapiens | penultimate step of the purine de novo synthesis pathway | tetrahydrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazole-4-carboxamide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P31939 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazole-4-carboxamide | - |
Homo sapiens | tetrahydrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazole-4-carboxamide | - |
? | |
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazole-4-carboxamide | penultimate step of the purine de novo synthesis pathway | Homo sapiens | tetrahydrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazole-4-carboxamide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AICAR transformylase/inosine monophosphate cyclohydrolase | bifunctional enzyme catalyzing the last two steps of the purine de novo synthesis pathway | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
10-formyltetrahydrofolate | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000015 | - |
NSC30171 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0006 | - |
IC50: 0.0006 mM | Homo sapiens | NSC30171 | |
0.003 | - |
IC50: 0.003 mM | Homo sapiens | NSC47729 | |
0.004 | - |
IC50: 0.004 mM | Homo sapiens | NSC37173 | |
0.008 | - |
IC50: 0.008 mM | Homo sapiens | NSC37031 | |
0.008 | - |
IC50: 0.008 mM | Homo sapiens | NSC58046 | |
0.009 | - |
IC50: 0.009 mM | Homo sapiens | NSC292213 | |
0.01 | - |
IC50: 0.010mM | Homo sapiens | NSC126445 | |
0.012 | - |
IC50: 0.012 mM | Homo sapiens | NSC326203 | |
0.012 | - |
IC50: 0.012 mM | Homo sapiens | NSC45592 | |
0.012 | - |
IC50: 0.012 mM | Homo sapiens | NSC324572 | |
0.014 | - |
IC50: 0.014 mM | Homo sapiens | NSC88915 | |
0.017 | - |
IC50: 0.017 mM | Homo sapiens | NSC26699 | |
0.02 | - |
IC50: 0.020 mM | Homo sapiens | NSC324981 | |
0.02 | - |
IC50: 0.020 mM | Homo sapiens | NSC324571 | |
0.036 | - |
IC50: 0.036 mM | Homo sapiens | NSC170645 | |
0.055 | - |
IC50: 0.055 mM | Homo sapiens | NSC41806 | |
0.106 | - |
IC50: 0.106 mM | Homo sapiens | NSC321237 | |
0.204 | - |
IC50: 0.204 mM | Homo sapiens | NSC326211 | |
0.231 | - |
IC50: 0.231 mM | Homo sapiens | NSC7524 |