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Literature summary for 2.1.2.3 extracted from

  • Bulock, K.G.; Beardsley, G.P.; Anderson, K.S.
    The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase): A surprising lack of substrate channeling (2002), J. Biol. Chem., 277, 22168-22174.
    View publication on PubMed
Search for more literature for 2.1.2.3

Application

Application Comment Organism
medicine
-
 Gallus sp.
medicine target for development of inhibitors with potential use as chemotherapeutic agents Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
ATIC complex crystallized in monoclinic space group P2(1), a = 56.48 A, b = 107.88 A, c = 103.86 A and beta = 91.2° Gallus sp.

Inhibitors

Inhibitors Comment Organism Structure
(6S/R)-5,10-dideaza-5,6,7,8,-tetrahydrofolate
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01
-
 10-formyltetrahydrofolate
-
 Homo sapiens
0.185
-
 tetrahydrofolate
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide Homo sapiens penultimate and final steps in the de novo purine biosynthesis pathway tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide Gallus sp. penultimate and final steps in the de novo purine biosynthesis pathway tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide Homo sapiens reduced folate cofactor requiring step of de novo purine biosynthesis tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide Gallus sp. reduced folate cofactor requiring step of de novo purine biosynthesis tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r

Organism

Organism UniProt Comment Textmining
Gallus sp.
-
 avian
-
Homo sapiens
-
 human
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide penultimate and final steps in the de novo purine biosynthesis pathway Homo sapiens tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide penultimate and final steps in the de novo purine biosynthesis pathway Gallus sp. tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide reduced folate cofactor requiring step of de novo purine biosynthesis Homo sapiens tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide reduced folate cofactor requiring step of de novo purine biosynthesis Gallus sp. tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r
additional information in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene Homo sapiens ?
-
 ?
additional information in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene Gallus sp. ?
-
 ?
N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide
-
 Homo sapiens tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide
-
 r
N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide
-
 Gallus sp. tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide
-
 r

Synonyms

Synonyms Comment Organism
AICARFT
-
 Homo sapiens
ATIC
-
 Homo sapiens
ATIC
-
 Gallus sp.

Cofactor

Cofactor Comment Organism Structure
N10-formyltetrahydrofolate
-
 Homo sapiens
N10-formyltetrahydrofolate
-
 Gallus sp.