Crystallization (Comment) | Organism |
---|---|
ATIC complex crystallized in monoclinic space group P2(1), a = 56.48 A, b = 107.88 A, c = 103.86 A and beta = 91.2° | Gallus sp. |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00099 | - |
N10-formyltetrahydropteroyltetraglutamate | 25 mM KCl | Gallus sp. | |
0.00107 | - |
N10-formyltetrahydropteroyltetraglutamate | 150 mM KCl | Gallus sp. | |
0.00164 | - |
N10-formyltetrahydropteroylhexaglutamate | 25 mM KCl | Gallus sp. | |
0.00165 | - |
N10-formyltetrahydropteroylmonoglutamate | 25 mM KCl | Gallus sp. | |
0.00183 | - |
N10-formyltetrahydropteroylheptaglutamate | 25 mM KCl | Gallus sp. | |
0.00195 | - |
N10-formyltetrahydropteroylhexaglutamate | 150 mM KCl | Gallus sp. | |
0.00206 | - |
N10-formyltetrahydropteroylpentaglutamate | 150 mM KCl | Gallus sp. | |
0.00256 | - |
N10-formyltetrahydropteroylpentaglutamate | 25 mM KCl | Gallus sp. | |
0.00313 | - |
N10-formyltetrahydropteroylheptaglutamate | 150 mM KCl | Gallus sp. | |
0.00595 | - |
N10-formyltetrahydropteroyltriglutamate | 150 mM KCl | Gallus sp. | |
0.353 | - |
N10-formyltetrahydropteroylmonoglutamate | 150 mM KCl | Gallus sp. | |
0.674 | - |
N10-formyltetrahydropteroyltriglutamate | 25 mM KCl | Gallus sp. |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
K+ | required for maximum enzymatic activity | Gallus sp. |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | Gallus sp. | - |
tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
N10-formyltetrahydropteroylglutamate + 5'-phosphoribosyl-5-formamido-4-imidazole carboxamide ribonucleotide | Gallus sp. | - |
tetrahydropteroylglutamate + 5'-phosphoribosyl-5-formamido-4-imidazole carboxamide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus sp. | - |
chicken | - |
Purification (Comment) | Organism |
---|---|
- |
Gallus sp. |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Gallus sp. | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0371 | - |
- |
Gallus sp. |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | - |
Gallus sp. | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
additional information | in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene | Gallus sp. | ? | - |
? | |
N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide | - |
Gallus sp. | tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide | - |
r | |
N10-formyltetrahydropteroylglutamate + 5'-phosphoribosyl-5-formamido-4-imidazole carboxamide ribonucleotide | - |
Gallus sp. | tetrahydropteroylglutamate + 5'-phosphoribosyl-5-formamido-4-imidazole carboxamide ribonucleotide | - |
? | |
N10-formyltetrahydropteroylglutamate + 5'-phosphoribosyl-5-formamido-4-imidazole carboxamide ribonucleotide | - |
Gallus sp. | tetrahydropteroylglutamate + 5'-phosphoribosyl-5-formamido-4-imidazole carboxamide | - |
? | |
N10-formyltetrahydropteroylglutamate + 5'-phosphoribosyl-5-formamino-4-imidazole carboxamide ribonucleotide | - |
Gallus sp. | tetrahydropteroylglutamate + 5'-phosphoribosyl-5-formamido-4-imidazole carboxamide ribonucleotide | - |
? | |
N10-formyltetrahydropteroylheptaglutamate + 5'-phosphoribosyl-5-formamino-4-imidazole carboxamide ribonucleotide | - |
Gallus sp. | tetrahydropteroylglutamate + 5'-phosphoribosyl-5-formamido-4-imidazole carboxamide ribonucleotide | - |
? | |
N10-formyltetrahydropteroylhexaglutamate + 5'-phosphoribosyl-5-formamino-4-imidazole carboxamide ribonucleotide | - |
Gallus sp. | tetrahydropteroylglutamate + 5'-phosphoribosyl-5-formamido-4-imidazole carboxamide ribonucleotide | - |
? | |
N10-formyltetrahydropteroylmonoglutamate + 5'-phosphoribosyl-5-formamino-4-imidazole carboxamide ribonucleotide | - |
Gallus sp. | tetrahydropteroylmonoglutamate + 5'-phosphoribosyl-5-formamido-4-imidazole carboxamide ribonucleotide | - |
? | |
N10-formyltetrahydropteroylpentaglutamate + 5'-phosphoribosyl-5-formamino-4-imidazole carboxamide ribonucleotide | - |
Gallus sp. | tetrahydropteroylglutamate + 5'-phosphoribosyl-5-formamido-4-imidazole carboxamide ribonucleotide | - |
? | |
N10-formyltetrahydropteroyltetraglutamate + 5'-phosphoribosyl-5-formamino-4-imidazole carboxamide ribonucleotide | - |
Gallus sp. | tetrahydropteroylglutamate + 5'-phosphoribosyl-5-formamido-4-imidazole carboxamide ribonucleotide | - |
? | |
N10-formyltetrahydropteroyltriglutamate + 5'-phosphoribosyl-5-formamino-4-imidazole carboxamide ribonucleotide | - |
Gallus sp. | tetrahydorpteroylglutamate + 5'-phosphoribosyl-5-formamido-4-imidazole carboxamide ribonucleotide | - |
? |