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Literature summary for 2.1.1.86 extracted from

  • Vepachedu, V.R.; Ferry, J.G.
    Role of the fused corrinoid/methyl transfer protein CmtA during CO-dependent growth of Methanosarcina acetivorans (2012), J. Bacteriol., 194, 4161-4168.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.86

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Rosetta (DE3) cells Methanosarcina acetivorans

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.135
-
 5-Methyl-5,6,7,8-tetrahydromethanopterin at 37°C in 50 mM MOPS-KOH (pH 7.0) Methanosarcina acetivorans
0.277
-
 coenzyme M at 37°C in 50 mM MOPS-KOH (pH 7.0) Methanosarcina acetivorans

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm CmtA Methanosarcina acetivorans 5737
-
membrane MtrA-H Methanosarcina acetivorans 16020
-
soluble CmtA Methanosarcina acetivorans
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
69000
-
 x * 69000, SDS-PAGE Methanosarcina acetivorans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M Methanosarcina acetivorans
-
 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M
-
 ?
5-methyl-5,6,7,8-tetrahydrosarcinapterin + coenzyme M Methanosarcina acetivorans
-
 5,6,7,8-tetrahydrosarcinapterin + methyl-coenzyme M
-
 ?

Organism

Organism UniProt Comment Textmining
Methanosarcina acetivorans Q8THX4
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,6,7,8-tetrahydromethanopterin + methylcob(III)alamin
-
 Methanosarcina acetivorans 5-methyl-5,6,7,8-tetrahydromethanopterin + cob(III)alamin
-
 ?
5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M
-
 Methanosarcina acetivorans 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M
-
 ?
5-methyl-5,6,7,8-tetrahydrosarcinapterin + coenzyme M
-
 Methanosarcina acetivorans 5,6,7,8-tetrahydrosarcinapterin + methyl-coenzyme M
-
 ?

Subunits

Subunits Comment Organism
? x * 69000, SDS-PAGE Methanosarcina acetivorans

Synonyms

Synonyms Comment Organism
5-methyl-5,6,7,8-tetrahydromethanopterin:coenzyme M methyltransferase
-
 Methanosarcina acetivorans
5-methyl-5,6,7,8-tetrahydrosarcinapterin:coenzyme M methyltransferase
-
 Methanosarcina acetivorans
CH3-THMPT:HS-CoM methyltransferase
-
 Methanosarcina acetivorans
CH3-THMPT:HSCoM methyltransferase
-
 Methanosarcina acetivorans
CmtA
-
 Methanosarcina acetivorans
cytoplasmic methyltransferase A
-
 Methanosarcina acetivorans
MA4384
-
 Methanosarcina acetivorans
methyl-tetrahydromethanopterin:CoM methyltransferase
-
 Methanosarcina acetivorans
MtrA-H
-
 Methanosarcina acetivorans

General Information

General Information Comment Organism
physiological function CmtA is a soluble 5-methyl-5,6,7,8-tetrahydrosarcinapterin:coenzyme M methyltransferase postulated to supplement the membrane-bound 5-methyl-5,6,7,8-tetrahydromethanopterin:coenzyme M methyltransferase during CO-dependent growth of Methanosarcina acetivorans Methanosarcina acetivorans