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Literature summary for 2.1.1.8 extracted from

  • Cao, H.; Mei, Q.; Zhang, L.; Xu, J.
    C314T polymorphism in histamine N-methyltransferase gene and susceptibility to duodenal ulcer in Chinese population. (2008), Clin. Chim. Acta, 391, 130.
No PubMed abstract available

Application

Application Comment Organism
medicine the HNMT T314 allele frequency is lower in Chinese population than in American Caucasians. No association can be found in the involvement of HNMT C314T polymorphism in the susceptibility to duodenal ulcer Homo sapiens

Protein Variants

Protein Variants Comment Organism
C314T PCR reaction-restriction fragment length polymorphism assay is used to identify the polymorphism of the point mutation C314T of HNMT gene of 498 Chinese patients with duodenal ulcer and 151 healthy individuals. In normal controls, the allele frequency of HNMT T314 is 3.3%, which is significantly lower than American Caucasians. The HNMT T314 allele is detected in 3.5% of the duodenal ulcer patients. In cases and controls, the frequency of C/C genotypes are 93.0% and 93.4%, respectively. The HNMT T/T genotype is not found in this population. No significant differences is seen in both genotype frequencies and allele frequencies between duodenal ulcer groups and controls Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Synonyms

Synonyms Comment Organism
histamine N-methyltransferase
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Homo sapiens
HNMT
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Homo sapiens