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Literature summary for 2.1.1.8 extracted from
- Thr105Ile, a functional polymorphism of histamine N-methyltransferase, is associated with alcoholism in two independent populations (2005), Alcohol. Clin. Exp. Res., 29, 303-309.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | T105I mutation is more abundant among alcoholics from Finnish Caucasion and Plains Indian American populations. Decreased histamine level in central nervous system may be a risk factor in alcoholism and associated with higher levels of trait anxiety | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| T105I | functional polymorphism, about 50% reduction of enzyme activity | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
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Release 2023.1 (January 2023)
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