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Literature summary for 2.1.1.8 extracted from
- Impromidine, a potent inhibitor of histamine methyltransferase (HMT) and diamine oxidase (DAO) (1980), Biochem. Pharmacol., 29, 2897-2900.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| amodiaquine | - |
Rattus norvegicus |  |
| d-Chlorpheniramine | - |
Rattus norvegicus | |
| Dimaprit | - |
Rattus norvegicus | |
| ethylamine | - |
Rattus norvegicus | |
| Impromidine | competitive, reversible | Rattus norvegicus | |
| SKF 91488 | - |
Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + histamine | - |
Rattus norvegicus | S-adenosyl-L-homocysteine + Ntau-methylhistamine | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00005 | - |
Amodiaquin | - |
Rattus norvegicus | |
| 0.0007 | - |
d-Chlorpheniramine | - |
Rattus norvegicus | |
| 0.001 | - |
SKF 91488 | - |
Rattus norvegicus | |
| 0.008 | - |
Dimaprit | - |
Rattus norvegicus | |
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