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Literature summary for 2.1.1.8 extracted from

  • Francis, D.M.; Thompson, M.F.; Greaves, M.W.
    The kinetic properties and reaction mechanism of histamine methyltransferase from human skin (1980), Biochem. J., 187, 819-828.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.8

Inhibitors

Inhibitors Comment Organism Structure
1-Methylhistamine
-
 Homo sapiens
histamine 0.025-0.1 mM Homo sapiens
additional information not inhibitory: S-adenosyl-L-methionine Homo sapiens
S-adenosylhomocysteine
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Homo sapiens
0.0018
-
 S-adenosyl-L-methionine
-
 Homo sapiens
0.0042
-
 histamine
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens possible role in modulation of histamine mediated reactions in skin ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + Ntau-methylhistamine ordered sequential bi bi reaction mechanism with S-adenosylmethionine as the first substrate and histamine as the second substrate, 1-methylhistamine is the first product to leave and S-adenosylhomocysteine the second Homo sapiens
a
S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + Ntau-methylhistamine sequential reaction mechanism Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
skin
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information possible role in modulation of histamine mediated reactions in skin Homo sapiens ?
-
 ?
S-adenosyl-L-methionine + histamine
-
 Homo sapiens S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
 ?