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Literature summary for 2.1.1.74 extracted from

  • Chernyshev, A.; Fleischmann, T.; Kohen, A.
    Thymidyl biosynthesis enzymes as antibiotic targets (2007), Appl. Microbiol. Biotechnol., 74, 282-289.
    View publication on PubMed

Application

Application Comment Organism
medicine human pathogen, target for new antibiotics Geobacillus stearothermophilus
medicine human pathogen, target for new antibiotics Mycobacterium leprae
medicine human pathogen, target for new antibiotics Mycobacterium tuberculosis
medicine human pathogen, target for new antibiotics Clostridium acidi-urici
medicine human pathogen, target for new antibiotics Clostridium botulinum
medicine human pathogen, target for new antibiotics Rickettsia sp.
medicine human pathogen, target for new antibiotics Bacillus anthracis
medicine human pathogen, target for new antibiotics Treponema palladium

Organism

Organism UniProt Comment Textmining
Bacillus anthracis
-
-
-
Clostridium acidi-urici
-
-
-
Clostridium botulinum
-
-
-
Geobacillus stearothermophilus
-
-
-
Mycobacterium leprae
-
-
-
Mycobacterium tuberculosis
-
-
-
Rickettsia sp.
-
-
-
Treponema palladium
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydrofolate + tRNA UpsiC + FADH2
-
Geobacillus stearothermophilus tetrahydrofolate + tRNA TpsiC + FAD
-
?
5,10-methylenetetrahydrofolate + tRNA UpsiC + FADH2
-
Mycobacterium leprae tetrahydrofolate + tRNA TpsiC + FAD
-
?
5,10-methylenetetrahydrofolate + tRNA UpsiC + FADH2
-
Mycobacterium tuberculosis tetrahydrofolate + tRNA TpsiC + FAD
-
?
5,10-methylenetetrahydrofolate + tRNA UpsiC + FADH2
-
Clostridium acidi-urici tetrahydrofolate + tRNA TpsiC + FAD
-
?
5,10-methylenetetrahydrofolate + tRNA UpsiC + FADH2
-
Clostridium botulinum tetrahydrofolate + tRNA TpsiC + FAD
-
?
5,10-methylenetetrahydrofolate + tRNA UpsiC + FADH2
-
Rickettsia sp. tetrahydrofolate + tRNA TpsiC + FAD
-
?
5,10-methylenetetrahydrofolate + tRNA UpsiC + FADH2
-
Bacillus anthracis tetrahydrofolate + tRNA TpsiC + FAD
-
?
5,10-methylenetetrahydrofolate + tRNA UpsiC + FADH2
-
Treponema palladium tetrahydrofolate + tRNA TpsiC + FAD
-
?

Synonyms

Synonyms Comment Organism
FDRTS
-
Geobacillus stearothermophilus
FDRTS
-
Mycobacterium leprae
FDRTS
-
Mycobacterium tuberculosis
FDRTS
-
Clostridium acidi-urici
FDRTS
-
Clostridium botulinum
FDRTS
-
Rickettsia sp.
FDRTS
-
Bacillus anthracis
FDRTS
-
Treponema palladium
folate-dependent ribothymidyl synthase
-
Geobacillus stearothermophilus
folate-dependent ribothymidyl synthase
-
Mycobacterium leprae
folate-dependent ribothymidyl synthase
-
Mycobacterium tuberculosis
folate-dependent ribothymidyl synthase
-
Clostridium acidi-urici
folate-dependent ribothymidyl synthase
-
Clostridium botulinum
folate-dependent ribothymidyl synthase
-
Rickettsia sp.
folate-dependent ribothymidyl synthase
-
Bacillus anthracis
folate-dependent ribothymidyl synthase
-
Treponema palladium

Cofactor

Cofactor Comment Organism Structure
FADH2
-
Geobacillus stearothermophilus
FADH2
-
Mycobacterium leprae
FADH2
-
Mycobacterium tuberculosis
FADH2
-
Clostridium acidi-urici
FADH2
-
Clostridium botulinum
FADH2
-
Rickettsia sp.
FADH2
-
Bacillus anthracis
FADH2
-
Treponema palladium