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Literature summary for 2.1.1.72 extracted from

  • Obarska, A.; Blundell, A.; Feder, M.; Vejsadova, S.; Sisakova, E.; Weiserova, M.; Bujnicki, J.M.; Firman, K.
    Structural model for the multisubunit Type IC restriction-modification DNA methyltransferase M.EcoR124I in complex with DNA (2006), Nucleic Acids Res., 34, 1992-2005.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
analysis structural model of the type IC M.EcoR124I DNA methyltransferase, comprising the HsdS subunit, two HsdM subunits, the cofactor S-adenosyl-L-methionine and the substrate DNA molecule Escherichia coli

Protein Variants

Protein Variants Comment Organism
E200G produces wild-type phenotype Escherichia coli
K184N restriction-deficiency Escherichia coli
L175P slightly lowers the ability of the restriction enzyme to cut DNA Escherichia coli
P218S loss of ability to bind DNA Escherichia coli
R163Q produces wild-type phenotype Escherichia coli
S154P produces wild-type phenotype Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli P10484
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + DNA adenine
-
Escherichia coli S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
?

Synonyms

Synonyms Comment Organism
type IC M.EcoR124I DNA methyltransferase
-
Escherichia coli